TY - JOUR
T1 - Short Communication
T2 - Results of a Consensus Conference on Radiotherapy for Brain and Bone Metastases within the Interreg-Project TreaT
AU - Rades, Dirk
AU - Kristiansen, Charlotte
AU - Schild, Steven E.
AU - Janssen, Stefan
N1 - Publisher Copyright:
© 2023 Authors. All rights reserved.
PY - 2023/3
Y1 - 2023/3
N2 - Background/Aim: Differences between radiotherapy for metastases in Northern Germany and Southern Denmark were previously identified, which led to a consensus conference. Patients and Methods: A consensus conference was held between three centers to harmonize radiotherapy regimens for bone and brain metastases. Results: Centers agreed on 1×8 Gy for painful bone metastases in patients with poor or intermediate survival prognoses and 10×3 Gy for favorable-prognosis patients. For complicated bone metastases, 5-6×4 Gy was preferred for poor-prognosis, 10×3 Gy for intermediate-prognosis, and longer-course radiotherapy for favorable-prognosis patients. For ≥5 brain metastases, centers agreed on whole-brain irradiation (WBI) with 5×4 Gy in poor-prognosis and longer-course regimens in other patients. For single brain lesions and patients with 2-4 lesions and intermediate/favorable prognoses, fractionated stereotactic radiotherapy (FSRT) or radiosurgery were recommended. No consensus was reached for 2-4 lesions in poor-prognosis patients; two centers preferred FSRT, one center WBI. Preferred radiotherapy regimens were similar for different age groups including elderly and very elderly patients, but age-specific survival scores were recommended. Conclusion: The consensus conference was successful, since harmonization of radiotherapy regimens was achieved for 32 of 33 possible situations.
AB - Background/Aim: Differences between radiotherapy for metastases in Northern Germany and Southern Denmark were previously identified, which led to a consensus conference. Patients and Methods: A consensus conference was held between three centers to harmonize radiotherapy regimens for bone and brain metastases. Results: Centers agreed on 1×8 Gy for painful bone metastases in patients with poor or intermediate survival prognoses and 10×3 Gy for favorable-prognosis patients. For complicated bone metastases, 5-6×4 Gy was preferred for poor-prognosis, 10×3 Gy for intermediate-prognosis, and longer-course radiotherapy for favorable-prognosis patients. For ≥5 brain metastases, centers agreed on whole-brain irradiation (WBI) with 5×4 Gy in poor-prognosis and longer-course regimens in other patients. For single brain lesions and patients with 2-4 lesions and intermediate/favorable prognoses, fractionated stereotactic radiotherapy (FSRT) or radiosurgery were recommended. No consensus was reached for 2-4 lesions in poor-prognosis patients; two centers preferred FSRT, one center WBI. Preferred radiotherapy regimens were similar for different age groups including elderly and very elderly patients, but age-specific survival scores were recommended. Conclusion: The consensus conference was successful, since harmonization of radiotherapy regimens was achieved for 32 of 33 possible situations.
UR - http://www.scopus.com/inward/record.url?scp=85149493340&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/62f113ab-c4cf-376a-8366-9b3c48b8301e/
U2 - 10.21873/invivo.13158
DO - 10.21873/invivo.13158
M3 - Journal articles
C2 - 36881061
AN - SCOPUS:85149493340
SN - 0258-851X
VL - 37
SP - 894
EP - 897
JO - In Vivo
JF - In Vivo
IS - 2
ER -