Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus

Olaf Jöhren; Steffi J. Neidert; Marco Kummer; Peter Dominiak

doi:10.1016/S0196-9781(02)00052-9

Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus

Olaf Jöhren^*, Steffi J. Neidert, Marco Kummer, Peter Dominiak

^*Corresponding author for this work

Institute of Experimental and Clinical Pharmacology and Toxicology

University of Kiel

45 Citations (Scopus)

Abstract

The neuropeptides orexin A and B are expressed in the lateral hypothalamic area and are involved in the regulation of energy homeostasis and arousal. Recent results showed gender differences in the expression of orexin receptor subtypes in rats. In the present study, we analyzed the mRNA expression of prepro-orexin (PPO) in the hypothalamus of male and female rats using quantitative real-time PCR. We found significantly higher levels of PPO mRNA in the hypothalamus of female rats compared to male rats. Our study indicates a sex-dependent regulation of hypothalamic PPO expression and suggests gender-specific functions of orexins.

Original language	English
Journal	Peptides
Volume	23
Issue number	6
Pages (from-to)	1177-1180
Number of pages	4
ISSN	0196-9781
DOIs	https://doi.org/10.1016/S0196-9781(02)00052-9
Publication status	Published - 30.07.2002

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1016/S0196-9781(02)00052-9

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abstract = "The neuropeptides orexin A and B are expressed in the lateral hypothalamic area and are involved in the regulation of energy homeostasis and arousal. Recent results showed gender differences in the expression of orexin receptor subtypes in rats. In the present study, we analyzed the mRNA expression of prepro-orexin (PPO) in the hypothalamus of male and female rats using quantitative real-time PCR. We found significantly higher levels of PPO mRNA in the hypothalamus of female rats compared to male rats. Our study indicates a sex-dependent regulation of hypothalamic PPO expression and suggests gender-specific functions of orexins.",

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AU - Jöhren, Olaf

AU - Neidert, Steffi J.

AU - Kummer, Marco

AU - Dominiak, Peter

PY - 2002/7/30

Y1 - 2002/7/30

N2 - The neuropeptides orexin A and B are expressed in the lateral hypothalamic area and are involved in the regulation of energy homeostasis and arousal. Recent results showed gender differences in the expression of orexin receptor subtypes in rats. In the present study, we analyzed the mRNA expression of prepro-orexin (PPO) in the hypothalamus of male and female rats using quantitative real-time PCR. We found significantly higher levels of PPO mRNA in the hypothalamus of female rats compared to male rats. Our study indicates a sex-dependent regulation of hypothalamic PPO expression and suggests gender-specific functions of orexins.

AB - The neuropeptides orexin A and B are expressed in the lateral hypothalamic area and are involved in the regulation of energy homeostasis and arousal. Recent results showed gender differences in the expression of orexin receptor subtypes in rats. In the present study, we analyzed the mRNA expression of prepro-orexin (PPO) in the hypothalamus of male and female rats using quantitative real-time PCR. We found significantly higher levels of PPO mRNA in the hypothalamus of female rats compared to male rats. Our study indicates a sex-dependent regulation of hypothalamic PPO expression and suggests gender-specific functions of orexins.

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ER -

Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus

Abstract

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