Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus

Olaf Jöhren*, Steffi J. Neidert, Marco Kummer, Peter Dominiak

*Corresponding author for this work
45 Citations (Scopus)


The neuropeptides orexin A and B are expressed in the lateral hypothalamic area and are involved in the regulation of energy homeostasis and arousal. Recent results showed gender differences in the expression of orexin receptor subtypes in rats. In the present study, we analyzed the mRNA expression of prepro-orexin (PPO) in the hypothalamus of male and female rats using quantitative real-time PCR. We found significantly higher levels of PPO mRNA in the hypothalamus of female rats compared to male rats. Our study indicates a sex-dependent regulation of hypothalamic PPO expression and suggests gender-specific functions of orexins.

Original languageEnglish
Issue number6
Pages (from-to)1177-1180
Number of pages4
Publication statusPublished - 30.07.2002

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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