Sex specifically associated promoter polymorphism in multiple sclerosis affects interleukin 4 expression levels

D. A. Akkad; L. Arning; S. M. Ibrahim; J. T. Epplen

doi:10.1038/sj.gene.6364429

Sex specifically associated promoter polymorphism in multiple sclerosis affects interleukin 4 expression levels

D. A. Akkad, L. Arning, S. M. Ibrahim, J. T. Epplen^*

^*Corresponding author for this work

Clinic of Dermatology, Allergology and Venerology

Ruhr-University Bochum

21 Citations (Scopus)

Abstract

The interleukin 4 promoter polymorphism -589 C/T (rs2243250) was genotyped in 869 multiple sclerosis (MS) patients and 595 healthy blood donors. Sex-specific MS association was evident whereas two flanking polymorphisms showed insignificant P values. In dual luciferase assays of cultured Jurkat cells the cloned promoter comprising the -589 T allele leads to higher expression as compared to the respective construct with the C allele. Together these findings may be discussed functionally as contributing to the genetic predisposition and to the pathogenesis in MS.

Original language	English
Journal	Genes and Immunity
Volume	8
Issue number	8
Pages (from-to)	703-706
Number of pages	4
ISSN	1466-4879
DOIs	https://doi.org/10.1038/sj.gene.6364429
Publication status	Published - 12.2007

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Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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abstract = "The interleukin 4 promoter polymorphism -589 C/T (rs2243250) was genotyped in 869 multiple sclerosis (MS) patients and 595 healthy blood donors. Sex-specific MS association was evident whereas two flanking polymorphisms showed insignificant P values. In dual luciferase assays of cultured Jurkat cells the cloned promoter comprising the -589 T allele leads to higher expression as compared to the respective construct with the C allele. Together these findings may be discussed functionally as contributing to the genetic predisposition and to the pathogenesis in MS.",

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AB - The interleukin 4 promoter polymorphism -589 C/T (rs2243250) was genotyped in 869 multiple sclerosis (MS) patients and 595 healthy blood donors. Sex-specific MS association was evident whereas two flanking polymorphisms showed insignificant P values. In dual luciferase assays of cultured Jurkat cells the cloned promoter comprising the -589 T allele leads to higher expression as compared to the respective construct with the C allele. Together these findings may be discussed functionally as contributing to the genetic predisposition and to the pathogenesis in MS.

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Sex specifically associated promoter polymorphism in multiple sclerosis affects interleukin 4 expression levels

Abstract

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