Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease

Carlo Wilke; Frank Gillardon; Christian Deuschle; Evelyn Dubois; Markus A Hobert; Jennifer Müller vom Hagen; Stefanie Krüger; Saskia Biskup; Cornelis Blauwendraat; Michael Hruscha; Stephan A Kaeser; Peter Heutink; Walter Maetzler; Matthis Synofzik

doi:10.2174/1567205013666160314151247

Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease

Carlo Wilke, Frank Gillardon, Christian Deuschle, Evelyn Dubois, Markus A Hobert, Jennifer Müller vom Hagen, Stefanie Krüger, Saskia Biskup, Cornelis Blauwendraat, Michael Hruscha, Stephan A Kaeser, Peter Heutink, Walter Maetzler, Matthis Synofzik

Clinic of Neurology

University of Tubingen

33 Citations (Scopus)

Abstract

Altered progranulin levels play a major role in neurodegenerative diseases, like Alzheimer's dementia (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), even in the absence of GRN mutations. Increasing progranulin levels could hereby provide a novel treatment strategy. However, knowledge on progranulin regulation in neurodegenerative diseases remains limited. We here demonstrate that cerebrospinal fluid progranulin levels do not correlate with its serum levels in AD, FTD and ALS, indicating a differential regulation of its central and peripheral levels in neurodegeneration. Blood progranulin levels thus do not reliably predict central nervous progranulin levels and their response to future progranulin-increasing therapeutics.

Original language	English
Journal	Current Alzheimer Research
Volume	13
Issue number	6
Pages (from-to)	654-62
Number of pages	9
ISSN	1567-2050
DOIs	https://doi.org/10.2174/1567205013666160314151247
Publication status	Published - 2016

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Wilke, C., Gillardon, F., Deuschle, C., Dubois, E., Hobert, M. A., Müller vom Hagen, J., Krüger, S., Biskup, S., Blauwendraat, C., Hruscha, M., Kaeser, S. A., Heutink, P., Maetzler, W., & Synofzik, M. (2016). Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease. Current Alzheimer Research, 13(6), 654-62. https://doi.org/10.2174/1567205013666160314151247

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title = "Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease",

abstract = "Altered progranulin levels play a major role in neurodegenerative diseases, like Alzheimer's dementia (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), even in the absence of GRN mutations. Increasing progranulin levels could hereby provide a novel treatment strategy. However, knowledge on progranulin regulation in neurodegenerative diseases remains limited. We here demonstrate that cerebrospinal fluid progranulin levels do not correlate with its serum levels in AD, FTD and ALS, indicating a differential regulation of its central and peripheral levels in neurodegeneration. Blood progranulin levels thus do not reliably predict central nervous progranulin levels and their response to future progranulin-increasing therapeutics.",

author = "Carlo Wilke and Frank Gillardon and Christian Deuschle and Evelyn Dubois and Hobert, \{Markus A\} and \{M{\"u}ller vom Hagen\}, Jennifer and Stefanie Kr{\"u}ger and Saskia Biskup and Cornelis Blauwendraat and Michael Hruscha and Kaeser, \{Stephan A\} and Peter Heutink and Walter Maetzler and Matthis Synofzik",

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doi = "10.2174/1567205013666160314151247",

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Wilke, C, Gillardon, F, Deuschle, C, Dubois, E, Hobert, MA, Müller vom Hagen, J, Krüger, S, Biskup, S, Blauwendraat, C, Hruscha, M, Kaeser, SA, Heutink, P, Maetzler, W & Synofzik, M 2016, 'Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease', Current Alzheimer Research, vol. 13, no. 6, pp. 654-62. https://doi.org/10.2174/1567205013666160314151247

TY - JOUR

T1 - Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease

AU - Wilke, Carlo

AU - Gillardon, Frank

AU - Deuschle, Christian

AU - Dubois, Evelyn

AU - Hobert, Markus A

AU - Müller vom Hagen, Jennifer

AU - Krüger, Stefanie

AU - Biskup, Saskia

AU - Blauwendraat, Cornelis

AU - Hruscha, Michael

AU - Kaeser, Stephan A

AU - Heutink, Peter

AU - Maetzler, Walter

AU - Synofzik, Matthis

PY - 2016

Y1 - 2016

N2 - Altered progranulin levels play a major role in neurodegenerative diseases, like Alzheimer's dementia (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), even in the absence of GRN mutations. Increasing progranulin levels could hereby provide a novel treatment strategy. However, knowledge on progranulin regulation in neurodegenerative diseases remains limited. We here demonstrate that cerebrospinal fluid progranulin levels do not correlate with its serum levels in AD, FTD and ALS, indicating a differential regulation of its central and peripheral levels in neurodegeneration. Blood progranulin levels thus do not reliably predict central nervous progranulin levels and their response to future progranulin-increasing therapeutics.

AB - Altered progranulin levels play a major role in neurodegenerative diseases, like Alzheimer's dementia (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), even in the absence of GRN mutations. Increasing progranulin levels could hereby provide a novel treatment strategy. However, knowledge on progranulin regulation in neurodegenerative diseases remains limited. We here demonstrate that cerebrospinal fluid progranulin levels do not correlate with its serum levels in AD, FTD and ALS, indicating a differential regulation of its central and peripheral levels in neurodegeneration. Blood progranulin levels thus do not reliably predict central nervous progranulin levels and their response to future progranulin-increasing therapeutics.

U2 - 10.2174/1567205013666160314151247

DO - 10.2174/1567205013666160314151247

M3 - Journal articles

C2 - 26971930

SN - 1567-2050

VL - 13

SP - 654

EP - 662

JO - Current Alzheimer Research

JF - Current Alzheimer Research

IS - 6

ER -

Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease

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