Serum erythropoietin levels in patients with sepsis and septic shock

Jörg Abel; Nestor Spannbrucker; Joachim Fandrey; Wolfgang Jelkmann

doi:10.1111/j.1600-0609.1996.tb01393.x

Serum erythropoietin levels in patients with sepsis and septic shock

Jörg Abel, Nestor Spannbrucker, Joachim Fandrey, Wolfgang Jelkmann^*

^*Corresponding author for this work

Institute of Physiology

University of Bonn

57 Citations (Scopus)

Abstract

The role of the immune system in the control of the production of erythropoietin is still poorly understood. Herein, the levels of circulating immunoreactive erythropoietin, tumour necrosis factor α, interleukin-1β and interleukin-6 were determined in 10 septic patients for up to 4 d following the admission to an internal intensive care unit. The data show that the production of erythropoietin was not suppressed despite an increase in the levels of proinflammatory cytokines. Circulating erythropoietin and interleukin-6 greatly increased in the 6 nonsurviving patients. The pattern of the serum erythropoietin level in the nonsurvivors resembled that of acute phase proteins and was independent of the blood haemoglobin concentration. Similar to interleukin 6, abnormally high serum erythropoietin levels appear to be a negative prognostic indicator in patients suffering from septic shock.

Original language	English
Journal	European Journal of Haematology
Volume	57
Issue number	5
Pages (from-to)	359-363
Number of pages	5
ISSN	0902-4441
DOIs	https://doi.org/10.1111/j.1600-0609.1996.tb01393.x
Publication status	Published - 1996

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1111/j.1600-0609.1996.tb01393.x

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title = "Serum erythropoietin levels in patients with sepsis and septic shock",

abstract = "The role of the immune system in the control of the production of erythropoietin is still poorly understood. Herein, the levels of circulating immunoreactive erythropoietin, tumour necrosis factor α, interleukin-1β and interleukin-6 were determined in 10 septic patients for up to 4 d following the admission to an internal intensive care unit. The data show that the production of erythropoietin was not suppressed despite an increase in the levels of proinflammatory cytokines. Circulating erythropoietin and interleukin-6 greatly increased in the 6 nonsurviving patients. The pattern of the serum erythropoietin level in the nonsurvivors resembled that of acute phase proteins and was independent of the blood haemoglobin concentration. Similar to interleukin 6, abnormally high serum erythropoietin levels appear to be a negative prognostic indicator in patients suffering from septic shock.",

author = "J{\"o}rg Abel and Nestor Spannbrucker and Joachim Fandrey and Wolfgang Jelkmann",

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language = "English",

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pages = "359--363",

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T1 - Serum erythropoietin levels in patients with sepsis and septic shock

AU - Abel, Jörg

AU - Spannbrucker, Nestor

AU - Fandrey, Joachim

AU - Jelkmann, Wolfgang

PY - 1996

Y1 - 1996

N2 - The role of the immune system in the control of the production of erythropoietin is still poorly understood. Herein, the levels of circulating immunoreactive erythropoietin, tumour necrosis factor α, interleukin-1β and interleukin-6 were determined in 10 septic patients for up to 4 d following the admission to an internal intensive care unit. The data show that the production of erythropoietin was not suppressed despite an increase in the levels of proinflammatory cytokines. Circulating erythropoietin and interleukin-6 greatly increased in the 6 nonsurviving patients. The pattern of the serum erythropoietin level in the nonsurvivors resembled that of acute phase proteins and was independent of the blood haemoglobin concentration. Similar to interleukin 6, abnormally high serum erythropoietin levels appear to be a negative prognostic indicator in patients suffering from septic shock.

AB - The role of the immune system in the control of the production of erythropoietin is still poorly understood. Herein, the levels of circulating immunoreactive erythropoietin, tumour necrosis factor α, interleukin-1β and interleukin-6 were determined in 10 septic patients for up to 4 d following the admission to an internal intensive care unit. The data show that the production of erythropoietin was not suppressed despite an increase in the levels of proinflammatory cytokines. Circulating erythropoietin and interleukin-6 greatly increased in the 6 nonsurviving patients. The pattern of the serum erythropoietin level in the nonsurvivors resembled that of acute phase proteins and was independent of the blood haemoglobin concentration. Similar to interleukin 6, abnormally high serum erythropoietin levels appear to be a negative prognostic indicator in patients suffering from septic shock.

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U2 - 10.1111/j.1600-0609.1996.tb01393.x

DO - 10.1111/j.1600-0609.1996.tb01393.x

M3 - Journal articles

C2 - 9003476

AN - SCOPUS:0030478414

SN - 0902-4441

VL - 57

SP - 359

EP - 363

JO - European Journal of Haematology

JF - European Journal of Haematology

IS - 5

ER -

Serum erythropoietin levels in patients with sepsis and septic shock

Abstract

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