Serum erythropoietin levels in patients with sepsis and septic shock

Jörg Abel, Nestor Spannbrucker, Joachim Fandrey, Wolfgang Jelkmann*

*Corresponding author for this work
54 Citations (Scopus)


The role of the immune system in the control of the production of erythropoietin is still poorly understood. Herein, the levels of circulating immunoreactive erythropoietin, tumour necrosis factor α, interleukin-1β and interleukin-6 were determined in 10 septic patients for up to 4 d following the admission to an internal intensive care unit. The data show that the production of erythropoietin was not suppressed despite an increase in the levels of proinflammatory cytokines. Circulating erythropoietin and interleukin-6 greatly increased in the 6 nonsurviving patients. The pattern of the serum erythropoietin level in the nonsurvivors resembled that of acute phase proteins and was independent of the blood haemoglobin concentration. Similar to interleukin 6, abnormally high serum erythropoietin levels appear to be a negative prognostic indicator in patients suffering from septic shock.

Original languageEnglish
JournalEuropean Journal of Haematology
Issue number5
Pages (from-to)359-363
Number of pages5
Publication statusPublished - 1996

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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