Serine-to-asparagine substitution in the GyrA gene leads to quinolone resistance in moxifloxacin-exposed Chlamydia pneumoniae

Jan Rupp; Andreas Gebert; Werner Solbach; Matthias Maass

doi:10.1128/AAC.49.1.406-407.2005

Serine-to-asparagine substitution in the GyrA gene leads to quinolone resistance in moxifloxacin-exposed Chlamydia pneumoniae

Jan Rupp, Andreas Gebert, Werner Solbach, Matthias Maass^*

^*Corresponding author for this work

Institute of Anatomy

Paracelsus Medical University

14 Citations (Scopus)

Abstract

Quinolone resistance of Chlamydia pneumoniae has not been described previously. Serial subcultures of C. pneumoniae under increasing moxifloxacin concentrations (0.0125 to 6.4 mg/liter) resulted in a 256-fold MIC increase compared to moxifloxacin-naive strains. GyrA gene sequencing revealed a novel point mutation with a Ser→Asn substitution. Subcultures under rifalazil and macrolides did not alter the respective MICs.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	49
Issue number	1
Pages (from-to)	406-407
Number of pages	2
ISSN	0066-4804
DOIs	https://doi.org/10.1128/AAC.49.1.406-407.2005
Publication status	Published - 01.01.2005

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Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1128/AAC.49.1.406-407.2005

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AU - Solbach, Werner

AU - Maass, Matthias

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AB - Quinolone resistance of Chlamydia pneumoniae has not been described previously. Serial subcultures of C. pneumoniae under increasing moxifloxacin concentrations (0.0125 to 6.4 mg/liter) resulted in a 256-fold MIC increase compared to moxifloxacin-naive strains. GyrA gene sequencing revealed a novel point mutation with a Ser→Asn substitution. Subcultures under rifalazil and macrolides did not alter the respective MICs.

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Serine-to-asparagine substitution in the GyrA gene leads to quinolone resistance in moxifloxacin-exposed Chlamydia pneumoniae

Abstract

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UN SDGs

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