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Sensitization of nociceptive ion channels by inhaled anesthetics - A pain in the gas?

Neil Harrison*, Carla Nau

*Corresponding author for this work

Abstract

A remarkable new article in this issue of Molecular Pharmacology (p. 1261) shows that the capsaicin-sensitive ion channel TRPV1 is sensitized to activation by chemical and physical stimuli in the presence of inhaled general anesthetics. This finding provides another example of an ion channel in which the anesthetic acts to modify channel gating. This may have important clinical implications in view of the role of TRPV1 in nociception.

Original languageEnglish
JournalMolecular Pharmacology
Volume74
Issue number5
Pages (from-to)1180-1182
Number of pages3
ISSN0026-895X
DOIs
Publication statusPublished - 11.2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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