Selective loss of cholinergic sudomotor fibers causes anhidrosis in ross syndrome

Claudia Sommer; Thies Lindenlaub; Detlef Zillikens; Klaus V. Toyka; Markus Naumann

doi:10.1002/ana.10256

Selective loss of cholinergic sudomotor fibers causes anhidrosis in ross syndrome

Claudia Sommer^*, Thies Lindenlaub, Detlef Zillikens, Klaus V. Toyka, Markus Naumann

^*Corresponding author for this work

Clinic of Dermatology, Allergology and Venerology

University of Würzburg

47 Citations (Scopus)

Abstract

Ross syndrome consists of segmental hyperhidrosis with widespread anhidrosis, Adie syndrome, and areflexia. The cause of this disorder is unknown. Selective degeneration of cholinergic fibers or of neural crest-derived structures has been suggested. We present clinical and skin biopsy data of 4 patients, providing evidence of reduced cholinergic sweat gland innervation in hypohidrotic skin by morphometric analysis. These findings indicate a selective degenerative process of the cholinergic sudomotor neurons.

Original language	English
Journal	Annals of Neurology
Volume	52
Issue number	2
Pages (from-to)	247-250
Number of pages	4
ISSN	0364-5134
DOIs	https://doi.org/10.1002/ana.10256
Publication status	Published - 2002

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1002/ana.10256

Cite this

@article{352f750d9c7f49e392da4dfc1fcd8f54,

title = "Selective loss of cholinergic sudomotor fibers causes anhidrosis in ross syndrome",

abstract = "Ross syndrome consists of segmental hyperhidrosis with widespread anhidrosis, Adie syndrome, and areflexia. The cause of this disorder is unknown. Selective degeneration of cholinergic fibers or of neural crest-derived structures has been suggested. We present clinical and skin biopsy data of 4 patients, providing evidence of reduced cholinergic sweat gland innervation in hypohidrotic skin by morphometric analysis. These findings indicate a selective degenerative process of the cholinergic sudomotor neurons.",

author = "Claudia Sommer and Thies Lindenlaub and Detlef Zillikens and Toyka, \{Klaus V.\} and Markus Naumann",

year = "2002",

doi = "10.1002/ana.10256",

language = "English",

volume = "52",

pages = "247--250",

journal = "Annals of Neurology",

issn = "0364-5134",

publisher = "John Wiley \& Sons Inc.",

number = "2",

}

TY - JOUR

T1 - Selective loss of cholinergic sudomotor fibers causes anhidrosis in ross syndrome

AU - Sommer, Claudia

AU - Lindenlaub, Thies

AU - Zillikens, Detlef

AU - Toyka, Klaus V.

AU - Naumann, Markus

PY - 2002

Y1 - 2002

N2 - Ross syndrome consists of segmental hyperhidrosis with widespread anhidrosis, Adie syndrome, and areflexia. The cause of this disorder is unknown. Selective degeneration of cholinergic fibers or of neural crest-derived structures has been suggested. We present clinical and skin biopsy data of 4 patients, providing evidence of reduced cholinergic sweat gland innervation in hypohidrotic skin by morphometric analysis. These findings indicate a selective degenerative process of the cholinergic sudomotor neurons.

AB - Ross syndrome consists of segmental hyperhidrosis with widespread anhidrosis, Adie syndrome, and areflexia. The cause of this disorder is unknown. Selective degeneration of cholinergic fibers or of neural crest-derived structures has been suggested. We present clinical and skin biopsy data of 4 patients, providing evidence of reduced cholinergic sweat gland innervation in hypohidrotic skin by morphometric analysis. These findings indicate a selective degenerative process of the cholinergic sudomotor neurons.

UR - https://www.scopus.com/pages/publications/0036322267

U2 - 10.1002/ana.10256

DO - 10.1002/ana.10256

M3 - Journal articles

C2 - 12210801

AN - SCOPUS:0036322267

SN - 0364-5134

VL - 52

SP - 247

EP - 250

JO - Annals of Neurology

JF - Annals of Neurology

IS - 2

ER -

Selective loss of cholinergic sudomotor fibers causes anhidrosis in ross syndrome

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this