TY - JOUR
T1 - Selection pressure for the factor-V-Leiden mutation and embryo implantation
AU - Göpel, Wolfgang
AU - Ludwig, Michael
AU - Junge, Ann K.
AU - Kohlmann, Thomas
AU - Diedrich, Klaus
AU - Möller, Jens
N1 - Funding Information:
This work was supported by grant Go 955/1–1 from the Deutsche Forschungsgemeinschaft and by Grant J 10 from the University of Lübeck.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2001/10/13
Y1 - 2001/10/13
N2 - The factor-V-Leiden mutation is seen in high frequencies in white people, despite its contribution to second-trimester abortion, preterm birth, and deep-vein thrombosis. The reason for its high frequency is not known. We investigated 102 mother-child pairs who had had successful in-vitro fertilisation by intracytoplasmic sperm injection as a model for human implantation. In 90% (9 of 10) of mother-child pairs who carried factor-V-Leiden mutation, the first embryo transfer was successful, compared with 49% (45 of 92) in factor-V-Leiden negative pairs (p=0.018, Fisher's exact test). Furthermore, the median number of unsuccessful transfers was lower in pairs who were positive for the mutation (0, range 0-2) than those who were negative (1, 0-8) (p=0.02, Mann Whitney U test) suggesting that improved implantation rate is an important genetic advantage of the factor-V-Leiden mutation.
AB - The factor-V-Leiden mutation is seen in high frequencies in white people, despite its contribution to second-trimester abortion, preterm birth, and deep-vein thrombosis. The reason for its high frequency is not known. We investigated 102 mother-child pairs who had had successful in-vitro fertilisation by intracytoplasmic sperm injection as a model for human implantation. In 90% (9 of 10) of mother-child pairs who carried factor-V-Leiden mutation, the first embryo transfer was successful, compared with 49% (45 of 92) in factor-V-Leiden negative pairs (p=0.018, Fisher's exact test). Furthermore, the median number of unsuccessful transfers was lower in pairs who were positive for the mutation (0, range 0-2) than those who were negative (1, 0-8) (p=0.02, Mann Whitney U test) suggesting that improved implantation rate is an important genetic advantage of the factor-V-Leiden mutation.
UR - http://www.scopus.com/inward/record.url?scp=0035856250&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(01)06354-1
DO - 10.1016/S0140-6736(01)06354-1
M3 - Journal articles
C2 - 11675065
AN - SCOPUS:0035856250
SN - 0140-6736
VL - 358
SP - 1238
EP - 1239
JO - Lancet
JF - Lancet
IS - 9289
ER -