Abstract
Surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) is a widely used technology platform for diagnostic biomarker discovery in tissue, plasma and serum. High-throughput and simplicity of experimental procedures have allowed this technology to become an important research tool for biomarker discovery during the last years. This review provides an overview of SELDI-TOF functionality, its advantages and drawbacks and gives a current literature overview of colorectal cancer based serum biomarker detection. Further improvements in instrumentation sensitivity and labelling chemistries will enable detection of novel, tissue-leakage biomarkers in serum. However, major emphasis should be given on subsequent identification of differentially observed protein peaks detected by SELDI-TOF. Clinical validation in large patient cohorts will then allow transferring novel biomarkers into clinical use.
| Original language | English |
|---|---|
| Journal | Archives of Physiology and Biochemistry |
| Volume | 116 |
| Issue number | 4-5 |
| Pages (from-to) | 188-196 |
| Number of pages | 9 |
| ISSN | 1381-3455 |
| DOIs | |
| Publication status | Published - 01.12.2010 |
Funding
Grants from the Werner and Klara Kreitz Foundation (Kiel, Schleswig-Holstein), the H.W. & J. Hector-Foundation (Weinheim), the Ad Infinitum Foundation (Lübeck), the Swedish Cancer Society (Cancerfonden), the Cancer Society Stockholm (Cancerföreningen) and the Swedish Research Council are gratefully acknowledged.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being -
SDG 9 Industry, Innovation, and Infrastructure
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