Abstract
A founder haplotype on chromosome 2p for autosomal dominant Parkinson's disease (PD) has been postulated for two families of Northern European descent, and a new mutation in the α-synuclein gene (Ala30Pro) has been found in a German PD family. We evaluated 85 German PD patients and 85 ethnically matched controls for shared markers on chromosome 2p and for the new α-synuclein mutation. We found no evidence for linkage disequilibrium, suggesting that the putative founder mutation on chromosome 2p is not a common cause of PD in the local population. Furthermore, no patient carried the Ala30Pro change, supporting earlier findings that mutations in the α-synuclein gene are extremely rare.
Original language | English |
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Journal | Annals of Human Genetics |
Volume | 63 |
Issue number | 4 |
Pages (from-to) | 285-291 |
Number of pages | 7 |
ISSN | 0003-4800 |
DOIs | |
Publication status | Published - 01.07.1999 |