Search for the PARK3 founder haplotype in a large cohort of patients with Parkinson's disease from Northern Germany

C. Klein, P. Vieregge, J. Hagenah, M. Sieberer, E. Doyle, H. Jacobs

17 Citations (Scopus)

Abstract

A founder haplotype on chromosome 2p for autosomal dominant Parkinson's disease (PD) has been postulated for two families of Northern European descent, and a new mutation in the α-synuclein gene (Ala30Pro) has been found in a German PD family. We evaluated 85 German PD patients and 85 ethnically matched controls for shared markers on chromosome 2p and for the new α-synuclein mutation. We found no evidence for linkage disequilibrium, suggesting that the putative founder mutation on chromosome 2p is not a common cause of PD in the local population. Furthermore, no patient carried the Ala30Pro change, supporting earlier findings that mutations in the α-synuclein gene are extremely rare.

Original languageEnglish
JournalAnnals of Human Genetics
Volume63
Issue number4
Pages (from-to)285-291
Number of pages7
ISSN0003-4800
DOIs
Publication statusPublished - 01.07.1999

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