Schizophrenia and apolipoprotein e gene polymorphism in Serbian population

Miljana Kecmanović; Valerija Dobričić; Rajna Dimitrijević; Dušan Keckarević; Dušanka Savić-Pavićević; Milica Keckarević-Marković; Maja Ivkovic; Stanka Romac

doi:10.3109/00207451003765956

Schizophrenia and apolipoprotein e gene polymorphism in Serbian population

Miljana Kecmanović, Valerija Dobričić, Rajna Dimitrijević, Dušan Keckarević, Dušanka Savić-Pavićević, Milica Keckarević-Marković, Maja Ivkovic, Stanka Romac

Institute of Neurogenetics

University of Belgrade

7 Citations (Scopus)

Abstract

Apolipoprotein E (APOE) gene variants are associated with alterations in brain function and increased risk of Alzheimer's disease (AD) and conflicting results have been reported in schizophrenia. Our results showed no significant differences in APOE allele or genotype frequencies between the Serbian schizophrenic patients and control individuals. However, we observed a possible association between particular subtypes of schizophrenia and APOE ε3/ε3 genotype (p = .01221) and ε4 allele showed a tendency toward positive association with responding to typical neuroleptics. APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia.

Original language	English
Journal	International Journal of Neuroscience
Volume	120
Issue number	7
Pages (from-to)	502-506
Number of pages	5
ISSN	0020-7454
DOIs	https://doi.org/10.3109/00207451003765956
Publication status	Published - 05.2010

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title = "Schizophrenia and apolipoprotein e gene polymorphism in Serbian population",

abstract = "Apolipoprotein E (APOE) gene variants are associated with alterations in brain function and increased risk of Alzheimer's disease (AD) and conflicting results have been reported in schizophrenia. Our results showed no significant differences in APOE allele or genotype frequencies between the Serbian schizophrenic patients and control individuals. However, we observed a possible association between particular subtypes of schizophrenia and APOE ε3/ε3 genotype (p = .01221) and ε4 allele showed a tendency toward positive association with responding to typical neuroleptics. APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia.",

author = "Miljana Kecmanovi{\'c} and Valerija Dobri{\v c}i{\'c} and Rajna Dimitrijevi{\'c} and Du{\v s}an Keckarevi{\'c} and Du{\v s}anka Savi{\'c}-Pavi{\'c}evi{\'c} and Milica Keckarevi{\'c}-Markovi{\'c} and Maja Ivkovic and Stanka Romac",

note = "Funding Information: This work was supported by Serbian Sciences, grant # 143013 (2006–2010).",

year = "2010",

month = may,

doi = "10.3109/00207451003765956",

language = "English",

volume = "120",

pages = "502--506",

journal = "International Journal of Neuroscience",

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TY - JOUR

T1 - Schizophrenia and apolipoprotein e gene polymorphism in Serbian population

AU - Kecmanović, Miljana

AU - Dobričić, Valerija

AU - Dimitrijević, Rajna

AU - Keckarević, Dušan

AU - Savić-Pavićević, Dušanka

AU - Keckarević-Marković, Milica

AU - Ivkovic, Maja

AU - Romac, Stanka

N1 - Funding Information: This work was supported by Serbian Sciences, grant # 143013 (2006–2010).

PY - 2010/5

Y1 - 2010/5

N2 - Apolipoprotein E (APOE) gene variants are associated with alterations in brain function and increased risk of Alzheimer's disease (AD) and conflicting results have been reported in schizophrenia. Our results showed no significant differences in APOE allele or genotype frequencies between the Serbian schizophrenic patients and control individuals. However, we observed a possible association between particular subtypes of schizophrenia and APOE ε3/ε3 genotype (p = .01221) and ε4 allele showed a tendency toward positive association with responding to typical neuroleptics. APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia.

AB - Apolipoprotein E (APOE) gene variants are associated with alterations in brain function and increased risk of Alzheimer's disease (AD) and conflicting results have been reported in schizophrenia. Our results showed no significant differences in APOE allele or genotype frequencies between the Serbian schizophrenic patients and control individuals. However, we observed a possible association between particular subtypes of schizophrenia and APOE ε3/ε3 genotype (p = .01221) and ε4 allele showed a tendency toward positive association with responding to typical neuroleptics. APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia.

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DO - 10.3109/00207451003765956

M3 - Journal articles

C2 - 20583903

AN - SCOPUS:77954195637

SN - 0020-7454

VL - 120

SP - 502

EP - 506

JO - International Journal of Neuroscience

JF - International Journal of Neuroscience

IS - 7

ER -

Schizophrenia and apolipoprotein e gene polymorphism in Serbian population

Abstract

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