TY - JOUR
T1 - Scalp recorded direct current (DC) potential shifts associated with food intake in hungry humans
AU - Schmitt, Beate
AU - Molle, Matthias
AU - Marshall, Lisa
AU - Hallschmid, Manfred
AU - Born, Jan
N1 - Funding Information:
We thank A. Otterbein for technical assistance. This research was supported by a grant from the Deutsche Forschungsgemeinschaft to J. Born.
PY - 2001/2/15
Y1 - 2001/2/15
N2 - In humans, eating is assumed to be regulated within a neuronal circuitry integrating hypothalamic 'feeding centers' with neocortical regions. Here, DC potentials were recorded in food deprived men to demonstrate a graded tuning of neocortical excitability in conjunction with meal ingestion. In the beginning of food ingestion a pronounced negative DC potential shift developed (P<0.01) which was replaced by a gradual positive potential shift reaching a maximum within 5 min after cessation of food intake (P<0.05). Both negative and positive shifts showed a widespread cortical distribution. The initial negative DC potential presumably reflecting increased depolarisation of apical cortical dendrites, may serve to facilitate eating behavior. The succeeding positivity points to a growing inhibitory influence on cortical processing with increasing satiety that may support termination of meal intake.
AB - In humans, eating is assumed to be regulated within a neuronal circuitry integrating hypothalamic 'feeding centers' with neocortical regions. Here, DC potentials were recorded in food deprived men to demonstrate a graded tuning of neocortical excitability in conjunction with meal ingestion. In the beginning of food ingestion a pronounced negative DC potential shift developed (P<0.01) which was replaced by a gradual positive potential shift reaching a maximum within 5 min after cessation of food intake (P<0.05). Both negative and positive shifts showed a widespread cortical distribution. The initial negative DC potential presumably reflecting increased depolarisation of apical cortical dendrites, may serve to facilitate eating behavior. The succeeding positivity points to a growing inhibitory influence on cortical processing with increasing satiety that may support termination of meal intake.
UR - http://www.scopus.com/inward/record.url?scp=0035866064&partnerID=8YFLogxK
U2 - 10.1016/S0166-4328(00)00338-7
DO - 10.1016/S0166-4328(00)00338-7
M3 - Journal articles
C2 - 11164529
AN - SCOPUS:0035866064
SN - 0166-4328
VL - 119
SP - 85
EP - 92
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -
