Saturation transfer difference measurements with SU(VAR)3-9 and S-adenosyl-L-methionine

Karsten Seeger; Sandro Lein; Gunter Reuter; Stefan Berger

doi:10.1021/bi047749x

Saturation transfer difference measurements with SU(VAR)3-9 and S-adenosyl-L-methionine

Karsten Seeger, Sandro Lein, Gunter Reuter, Stefan Berger

Institute of Chemistry and Metabolomics

9 Citations (Scopus)

Abstract

Saturation transfer difference NMR measurements were performed to investigate the interaction of S-adenosyl-l-methionine (AdoMet) with SU(VAR)3-9 from Drosophila melanogaster. SU(VAR)3-9 has a SET domain and plays an important role in methylation of lysine-9 of histone H3 which results in gene silencing. We determined the binding epitope of AdoMet and compared it with a crystal structure of another SET protein.

Original language	English
Title of host publication	Biochemistry
Number of pages	6
Publication date	26.04.2005
Pages	6208-6213
ISBN (Print)	0006-2960
DOIs	https://doi.org/10.1021/bi047749x
Publication status	Published - 26.04.2005

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10.1021/bi047749x

http://www.mendeley.com/research/saturation-transfer-difference-measurements-suvar39-sadenosyllmethionine

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abstract = "Saturation transfer difference NMR measurements were performed to investigate the interaction of S-adenosyl-l-methionine (AdoMet) with SU(VAR)3-9 from Drosophila melanogaster. SU(VAR)3-9 has a SET domain and plays an important role in methylation of lysine-9 of histone H3 which results in gene silencing. We determined the binding epitope of AdoMet and compared it with a crystal structure of another SET protein.",

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AU - Seeger, Karsten

AU - Lein, Sandro

AU - Reuter, Gunter

AU - Berger, Stefan

PY - 2005/4/26

Y1 - 2005/4/26

N2 - Saturation transfer difference NMR measurements were performed to investigate the interaction of S-adenosyl-l-methionine (AdoMet) with SU(VAR)3-9 from Drosophila melanogaster. SU(VAR)3-9 has a SET domain and plays an important role in methylation of lysine-9 of histone H3 which results in gene silencing. We determined the binding epitope of AdoMet and compared it with a crystal structure of another SET protein.

AB - Saturation transfer difference NMR measurements were performed to investigate the interaction of S-adenosyl-l-methionine (AdoMet) with SU(VAR)3-9 from Drosophila melanogaster. SU(VAR)3-9 has a SET domain and plays an important role in methylation of lysine-9 of histone H3 which results in gene silencing. We determined the binding epitope of AdoMet and compared it with a crystal structure of another SET protein.

U2 - 10.1021/bi047749x

DO - 10.1021/bi047749x

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T3 - Biochemistry

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BT - Biochemistry

ER -

Saturation transfer difference measurements with SU(VAR)3-9 and S-adenosyl-L-methionine

Abstract

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