Saturation transfer difference measurements with SU(VAR)3-9 and S-adenosyl-L-methionine

Karsten Seeger, Sandro Lein, Gunter Reuter, Stefan Berger


Saturation transfer difference NMR measurements were performed to investigate the interaction of S-adenosyl-l-methionine (AdoMet) with SU(VAR)3-9 from Drosophila melanogaster. SU(VAR)3-9 has a SET domain and plays an important role in methylation of lysine-9 of histone H3 which results in gene silencing. We determined the binding epitope of AdoMet and compared it with a crystal structure of another SET protein.
Original languageEnglish
Title of host publicationBiochemistry
Number of pages6
Publication date26.04.2005
ISBN (Print)0006-2960
Publication statusPublished - 26.04.2005


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