Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part Phase Ib/II study

Alessandro Rambaldi*, Alessandra Iurlo, Alessandro M. Vannucchi, Richard Noble, Nikolas von Bubnoff, Attilio Guarini, Bruno Martino, Antonio Pezzutto, Giuseppe Carli, Marianna De Muro, Stefania Luciani, Mary Frances McMullin, Nathalie Cambier, Jean Pierre Marolleau, Ruben A. Mesa, Raoul Tibes, Alessandro Pancrazzi, Francesca Gesullo, Paolo Bettica, Sara ManzoniSilvia Di Tollo

*Corresponding author for this work
40 Citations (Scopus)
Original languageEnglish
JournalLeukemia
Volume34
Issue number8
Pages (from-to)2234-2237
Number of pages4
ISSN0887-6924
DOIs
Publication statusPublished - 01.08.2020

Funding

Acknowledgements This study was funded by Italfarmaco S.p.A. David Young of Young Medical Communications and Consulting Ltd, a medical writer supported by funding from Italfarmaco S.p.A., provided drafts and editorial assistance to the authors during preparation of this paper. The authors would like to thank the investigators who recruited patients, including Dr Andrzej Hellmann, and the patients at the investigative sites for their support of this study. Conflict of interest AR has received honoraria for consultancy, and travel support from Italfarmaco, Gilead, Amgen, Novartis, Pfizer, Celgene, Sanofi, Astellas and Roche. AI has received speaker honoraria from Novartis, Pfizer and Incyte. AMV has received honoraria for advisory board participation from Novartis, Celgene, Incyte, CTI and Italfarmaco, and for lectures from Novartis, and CTI. N.v.B. received research funding from Novartis. MFM has received honoraria and has attended advisory boards with Novartis, and has received honoraria from Celgene. RAM has received honoraria as a consultant to Novartis, Sierra Oncology, and La Jolla Oncology, and research support from Incyte, Genentech, Celgene, CTI, and Abbvie. RT has advised and received honoraria from Italfarmaco. PB, SM, and SDT are employees of Italfarmaco SpA, the sponsor of the study. RN, AG, BM, AP, GC, MDM, SL, NC, J-PM, APancrazzi, FG have no conflicts to disclose.

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