Safety and efficacy of cryoballoon ablation for the treatment of atrial fibrillation in diabetic patients

Amr Abdin, Christian H. Heeger, Kivanc Yalin, Francesco Santoro, Natale Daniele Brunetti, Thomas Fink, Spyridon Liosis, Ben Brueggemann, Ahmad Keelani, Huong Lan Phan, Makoto Sano, Vanessa Sciacca, Evgeny Lyan, Dong An, Roza Meyer-Saraei, Feifan Ouyang, Karl Heinz Kuck, Charlotte Eitel, Julia Vogler, Roland Richard Tilz*

*Corresponding author for this work


Background: Cryoballoon based catheter ablation (CB-CA) is an established therapy for treatment of symptomatic atrial fibrillation (AF). However, data about AF ablation using the CB in the diabetic population is sparse. The aim of this single center retrospective study is to evaluate the safety and efficacy of CB ablation in patients with diabetes mellitus (DM) as compared to patients without DM. Methods and results: Between July 2015 and December 2017, 397 consecutive patients underwent CB-CA for AF. Forty-eight consecutive patients with DM (DM group, study group) were compared with propensity score-matched patients without DM (n=48, control group). All patients underwent pulmonary vein isolation (PVI) using the second-generation CB (CB2). The mean age in the DM group was 66.9±9.5 years and 69.5±8.8 in the non-DM group (p=0.18). During a follow-up of 12.7±5.1 months, single procedure success rate for the DM and the non-DM group was 68.7% and 70.8%, respectively (p=0.82). The most common complication was transient phrenic nerve palsy (4 DM group vs. 0 non-DM group, p=0.04). No severe complication such as procedure related deaths, atrio-esophageal fistula or cerebrovascular embolic events occurred. Conclusions: Our data strengthen the value of CB2 based ablation for the treatment of AF as an effective and safe procedure in DM patients, with similar success rates when compared with a non-DM population.

Original languageEnglish
JournalJournal of Atrial Fibrillation
Issue number6
Publication statusPublished - 2020


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