Rotenone, paraquat, and Parkinson's disease

Caroline M. Tanner; Freya Kame; G. Webster Ross; Jane A. Hoppin; Samuel M. Goldman; Monica Korell; Connie Marras; Grace S. Bhudhikanok; Meike Kasten; Anabel R. Chade; Kathleen Comyns; Marie Barber Richards; Cheryl Meng; Benjamin Priestley; Hubert H. Fernandez; Franca Cambi; David M. Umbach; Aaron Blair; Dale P. Sandler; J. William Langston

doi:10.1289/ehp.1002839

Rotenone, paraquat, and Parkinson's disease

Caroline M. Tanner, Freya Kame, G. Webster Ross, Jane A. Hoppin, Samuel M. Goldman, Monica Korell, Connie Marras, Grace S. Bhudhikanok, Meike Kasten, Anabel R. Chade, Kathleen Comyns, Marie Barber Richards, Cheryl Meng, Benjamin Priestley, Hubert H. Fernandez, Franca Cambi, David M. Umbach, Aaron Blair, Dale P. Sandler, J. William Langston

Clinic of Psychiatry and Psychotherapy

441 Citations (Scopus)

Abstract

Background: Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson's disease (PD). Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans.

Objectives: Our goal was to determine whether pesticides that cause mitochondrial dysfunction or oxidative stress are associated with PD or clinical features of parkinsonism in humans.

Methods: We assessed lifetime use of pesticides selected by mechanism in a case-control study nested in the Agricultural Health Study (AHS). PD was diagnosed by movement disorders specialists.

Controls were a stratified random sample of all AHS participants frequency-matched to cases by age, sex, and state at approximately three controls:one case.

Results: In 110 PD cases and 358 controls, PD was associated with use of a group of pesticides that inhibit mitochondrial complex I [odds ratio (OR) = 1.7; 95% confidence interval (CI), 1.0-2.8] including rotenone (OR = 2.5; 95% CI, 1.3-4.7) and with use of a group of pesticides that cause oxidative stress (OR = 2.0; 95% CI, 1.2-3.6), including paraquat (OR = 2.5; 95% CI, 1.4-4.7).

Conclusions: PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally-those that impair mitochondrial function and those that increase oxidative stress-supporting a role for these mechanisms in PD pathophysiology.

Original language	English
Journal	Environmental Health Perspectives
Volume	119
Issue number	6
Pages (from-to)	866-872
Number of pages	7
ISSN	0091-6765
DOIs	https://doi.org/10.1289/ehp.1002839
Publication status	Published - 01.06.2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1289/ehp.1002839

Cite this

Tanner, C. M., Kame, F., Ross, G. W., Hoppin, J. A., Goldman, S. M., Korell, M., Marras, C., Bhudhikanok, G. S., Kasten, M., Chade, A. R., Comyns, K., Richards, M. B., Meng, C., Priestley, B., Fernandez, H. H., Cambi, F., Umbach, D. M., Blair, A., Sandler, D. P., & Langston, J. W. (2011). Rotenone, paraquat, and Parkinson's disease. Environmental Health Perspectives, 119(6), 866-872. https://doi.org/10.1289/ehp.1002839

@article{ef6682d57a9b49689d0aaf98cb24fbc9,

title = "Rotenone, paraquat, and Parkinson's disease",

abstract = "Background: Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson's disease (PD). Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans. Objectives: Our goal was to determine whether pesticides that cause mitochondrial dysfunction or oxidative stress are associated with PD or clinical features of parkinsonism in humans. Methods: We assessed lifetime use of pesticides selected by mechanism in a case-control study nested in the Agricultural Health Study (AHS). PD was diagnosed by movement disorders specialists.Controls were a stratified random sample of all AHS participants frequency-matched to cases by age, sex, and state at approximately three controls:one case.Results: In 110 PD cases and 358 controls, PD was associated with use of a group of pesticides that inhibit mitochondrial complex I [odds ratio (OR) = 1.7; 95% confidence interval (CI), 1.0-2.8] including rotenone (OR = 2.5; 95% CI, 1.3-4.7) and with use of a group of pesticides that cause oxidative stress (OR = 2.0; 95% CI, 1.2-3.6), including paraquat (OR = 2.5; 95% CI, 1.4-4.7). Conclusions: PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally-those that impair mitochondrial function and those that increase oxidative stress-supporting a role for these mechanisms in PD pathophysiology.",

author = "Tanner, {Caroline M.} and Freya Kame and Ross, {G. Webster} and Hoppin, {Jane A.} and Goldman, {Samuel M.} and Monica Korell and Connie Marras and Bhudhikanok, {Grace S.} and Meike Kasten and Chade, {Anabel R.} and Kathleen Comyns and Richards, {Marie Barber} and Cheryl Meng and Benjamin Priestley and Fernandez, {Hubert H.} and Franca Cambi and Umbach, {David M.} and Aaron Blair and Sandler, {Dale P.} and Langston, {J. William}",

year = "2011",

month = jun,

day = "1",

doi = "10.1289/ehp.1002839",

language = "English",

volume = "119",

pages = "866--872",

journal = "Environmental Health Perspectives",

issn = "0091-6765",

number = "6",

}

Tanner, CM, Kame, F, Ross, GW, Hoppin, JA, Goldman, SM, Korell, M, Marras, C, Bhudhikanok, GS, Kasten, M, Chade, AR, Comyns, K, Richards, MB, Meng, C, Priestley, B, Fernandez, HH, Cambi, F, Umbach, DM, Blair, A, Sandler, DP & Langston, JW 2011, 'Rotenone, paraquat, and Parkinson's disease', Environmental Health Perspectives, vol. 119, no. 6, pp. 866-872. https://doi.org/10.1289/ehp.1002839

TY - JOUR

T1 - Rotenone, paraquat, and Parkinson's disease

AU - Tanner, Caroline M.

AU - Kame, Freya

AU - Ross, G. Webster

AU - Hoppin, Jane A.

AU - Goldman, Samuel M.

AU - Korell, Monica

AU - Marras, Connie

AU - Bhudhikanok, Grace S.

AU - Kasten, Meike

AU - Chade, Anabel R.

AU - Comyns, Kathleen

AU - Richards, Marie Barber

AU - Meng, Cheryl

AU - Priestley, Benjamin

AU - Fernandez, Hubert H.

AU - Cambi, Franca

AU - Umbach, David M.

AU - Blair, Aaron

AU - Sandler, Dale P.

AU - Langston, J. William

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Background: Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson's disease (PD). Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans. Objectives: Our goal was to determine whether pesticides that cause mitochondrial dysfunction or oxidative stress are associated with PD or clinical features of parkinsonism in humans. Methods: We assessed lifetime use of pesticides selected by mechanism in a case-control study nested in the Agricultural Health Study (AHS). PD was diagnosed by movement disorders specialists.Controls were a stratified random sample of all AHS participants frequency-matched to cases by age, sex, and state at approximately three controls:one case.Results: In 110 PD cases and 358 controls, PD was associated with use of a group of pesticides that inhibit mitochondrial complex I [odds ratio (OR) = 1.7; 95% confidence interval (CI), 1.0-2.8] including rotenone (OR = 2.5; 95% CI, 1.3-4.7) and with use of a group of pesticides that cause oxidative stress (OR = 2.0; 95% CI, 1.2-3.6), including paraquat (OR = 2.5; 95% CI, 1.4-4.7). Conclusions: PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally-those that impair mitochondrial function and those that increase oxidative stress-supporting a role for these mechanisms in PD pathophysiology.

AB - Background: Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson's disease (PD). Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans. Objectives: Our goal was to determine whether pesticides that cause mitochondrial dysfunction or oxidative stress are associated with PD or clinical features of parkinsonism in humans. Methods: We assessed lifetime use of pesticides selected by mechanism in a case-control study nested in the Agricultural Health Study (AHS). PD was diagnosed by movement disorders specialists.Controls were a stratified random sample of all AHS participants frequency-matched to cases by age, sex, and state at approximately three controls:one case.Results: In 110 PD cases and 358 controls, PD was associated with use of a group of pesticides that inhibit mitochondrial complex I [odds ratio (OR) = 1.7; 95% confidence interval (CI), 1.0-2.8] including rotenone (OR = 2.5; 95% CI, 1.3-4.7) and with use of a group of pesticides that cause oxidative stress (OR = 2.0; 95% CI, 1.2-3.6), including paraquat (OR = 2.5; 95% CI, 1.4-4.7). Conclusions: PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally-those that impair mitochondrial function and those that increase oxidative stress-supporting a role for these mechanisms in PD pathophysiology.

UR - http://www.scopus.com/inward/record.url?scp=79955557808&partnerID=8YFLogxK

U2 - 10.1289/ehp.1002839

DO - 10.1289/ehp.1002839

M3 - Journal articles

C2 - 21269927

AN - SCOPUS:79955557808

SN - 0091-6765

VL - 119

SP - 866

EP - 872

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

IS - 6

ER -

Rotenone, paraquat, and Parkinson's disease

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this