TY - JOUR
T1 - Role of sGC-dependent NO signalling and myocardial infarction risk
AU - Wobst, Jana
AU - Kessler, Thorsten
AU - Dang, Tan An
AU - Erdmann, Jeanette
AU - Schunkert, Heribert
PY - 2015/3/20
Y1 - 2015/3/20
N2 - The NO/cGMP pathway plays an important role in many physiological functions and pathophysiological conditions. In the last few years, several genetic and functional studies pointed to an underestimated role of this pathway in the development of atherosclerosis. Indeed, several genetic variants of key enzymes modulating the generation of NO and cGMP have been strongly associated with coronary artery disease and myocardial infarction risk. In this review, we aim to place the genomic findings on components of the NO/cGMP pathway, namely endothelial nitric oxide synthase, soluble guanylyl cyclase and phosphodiesterase 5A, in context of preventive and therapeutic strategies for treating atherosclerosis and its sequelae.
AB - The NO/cGMP pathway plays an important role in many physiological functions and pathophysiological conditions. In the last few years, several genetic and functional studies pointed to an underestimated role of this pathway in the development of atherosclerosis. Indeed, several genetic variants of key enzymes modulating the generation of NO and cGMP have been strongly associated with coronary artery disease and myocardial infarction risk. In this review, we aim to place the genomic findings on components of the NO/cGMP pathway, namely endothelial nitric oxide synthase, soluble guanylyl cyclase and phosphodiesterase 5A, in context of preventive and therapeutic strategies for treating atherosclerosis and its sequelae.
UR - http://www.scopus.com/inward/record.url?scp=84925504575&partnerID=8YFLogxK
U2 - 10.1007/s00109-015-1265-3
DO - 10.1007/s00109-015-1265-3
M3 - Scientific review articles
C2 - 25733135
AN - SCOPUS:84925504575
SN - 0946-2716
VL - 93
SP - 383
EP - 394
JO - Journal of Molecular Medicine
JF - Journal of Molecular Medicine
IS - 4
ER -
