Role of sGC-dependent NO signalling and myocardial infarction risk

Jana Wobst, Thorsten Kessler, Tan An Dang, Jeanette Erdmann, Heribert Schunkert*

*Corresponding author for this work
7 Citations (Scopus)


The NO/cGMP pathway plays an important role in many physiological functions and pathophysiological conditions. In the last few years, several genetic and functional studies pointed to an underestimated role of this pathway in the development of atherosclerosis. Indeed, several genetic variants of key enzymes modulating the generation of NO and cGMP have been strongly associated with coronary artery disease and myocardial infarction risk. In this review, we aim to place the genomic findings on components of the NO/cGMP pathway, namely endothelial nitric oxide synthase, soluble guanylyl cyclase and phosphodiesterase 5A, in context of preventive and therapeutic strategies for treating atherosclerosis and its sequelae.

Original languageEnglish
JournalJournal of Molecular Medicine
Issue number4
Pages (from-to)383-394
Number of pages12
Publication statusPublished - 20.03.2015


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