Role of ethnicity on the association of MAPT H1 haplotypes and subhaplotypes in Parkinson's disease

Susan Winkler; Inke R. König; Katja Lohmann-Hedrich; Peter Vieregge; Vladimir Kostic; Christine Klein

doi:10.1038/sj.ejhg.5201901

Role of ethnicity on the association of MAPT H1 haplotypes and subhaplotypes in Parkinson's disease

Susan Winkler, Inke R. König, Katja Lohmann-Hedrich, Peter Vieregge, Vladimir Kostic, Christine Klein^*

^*Corresponding author for this work

24 Citations (Scopus)

Abstract

An association of the H1 haplotype and subhaplotypes in the microtubule-associated protein Tau (MAPT) gene with Parkinson's disease (PD) has been reported. To further evaluate their role in PD, we genotyped a sample set of 765 cases and controls consisting of two large European subgroups of German (n = 418) and Serbian (n = 347) origin for the MAPT haplotypes H1 and H2. The H1/H1 carriers were tested for three additional MAPT polymorphisms. In the Serbian sample, there was significant evidence (P = 0.0108) of an association of the H1/H1 genotype and PD. Surprisingly, in the German sample, we did not find significant differences in genotype or haplotype frequencies between patients and controls. These results suggest that the role of H1 haplotypes in the etiology of PD may be ethnically dependent.

Original language	English
Journal	European Journal of Human Genetics
Volume	15
Issue number	11
Pages (from-to)	1163-1168
Number of pages	6
ISSN	1018-4813
DOIs	https://doi.org/10.1038/sj.ejhg.5201901
Publication status	Published - 01.11.2007

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title = "Role of ethnicity on the association of MAPT H1 haplotypes and subhaplotypes in Parkinson's disease",

abstract = "An association of the H1 haplotype and subhaplotypes in the microtubule-associated protein Tau (MAPT) gene with Parkinson's disease (PD) has been reported. To further evaluate their role in PD, we genotyped a sample set of 765 cases and controls consisting of two large European subgroups of German (n = 418) and Serbian (n = 347) origin for the MAPT haplotypes H1 and H2. The H1/H1 carriers were tested for three additional MAPT polymorphisms. In the Serbian sample, there was significant evidence (P = 0.0108) of an association of the H1/H1 genotype and PD. Surprisingly, in the German sample, we did not find significant differences in genotype or haplotype frequencies between patients and controls. These results suggest that the role of H1 haplotypes in the etiology of PD may be ethnically dependent.",

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T1 - Role of ethnicity on the association of MAPT H1 haplotypes and subhaplotypes in Parkinson's disease

AU - Winkler, Susan

AU - König, Inke R.

AU - Lohmann-Hedrich, Katja

AU - Vieregge, Peter

AU - Kostic, Vladimir

AU - Klein, Christine

PY - 2007/11/1

Y1 - 2007/11/1

N2 - An association of the H1 haplotype and subhaplotypes in the microtubule-associated protein Tau (MAPT) gene with Parkinson's disease (PD) has been reported. To further evaluate their role in PD, we genotyped a sample set of 765 cases and controls consisting of two large European subgroups of German (n = 418) and Serbian (n = 347) origin for the MAPT haplotypes H1 and H2. The H1/H1 carriers were tested for three additional MAPT polymorphisms. In the Serbian sample, there was significant evidence (P = 0.0108) of an association of the H1/H1 genotype and PD. Surprisingly, in the German sample, we did not find significant differences in genotype or haplotype frequencies between patients and controls. These results suggest that the role of H1 haplotypes in the etiology of PD may be ethnically dependent.

AB - An association of the H1 haplotype and subhaplotypes in the microtubule-associated protein Tau (MAPT) gene with Parkinson's disease (PD) has been reported. To further evaluate their role in PD, we genotyped a sample set of 765 cases and controls consisting of two large European subgroups of German (n = 418) and Serbian (n = 347) origin for the MAPT haplotypes H1 and H2. The H1/H1 carriers were tested for three additional MAPT polymorphisms. In the Serbian sample, there was significant evidence (P = 0.0108) of an association of the H1/H1 genotype and PD. Surprisingly, in the German sample, we did not find significant differences in genotype or haplotype frequencies between patients and controls. These results suggest that the role of H1 haplotypes in the etiology of PD may be ethnically dependent.

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Role of ethnicity on the association of MAPT H1 haplotypes and subhaplotypes in Parkinson's disease

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