TY - JOUR
T1 - Role of abca7 in human health and in alzheimer’s disease
AU - Dib, Shiraz
AU - Pahnke, Jens
AU - Gosselet, Fabien
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/4/27
Y1 - 2021/4/27
N2 - Several studies, including genome wide association studies (GWAS), have strongly sug-gested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer’s disease (AD). This ABC transporter is now considered as an important genetic deter-minant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.
AB - Several studies, including genome wide association studies (GWAS), have strongly sug-gested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer’s disease (AD). This ABC transporter is now considered as an important genetic deter-minant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.
UR - http://www.scopus.com/inward/record.url?scp=85104721017&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/01658389-74c9-3fa1-82c2-2e1c407e675f/
U2 - 10.3390/ijms22094603
DO - 10.3390/ijms22094603
M3 - Scientific review articles
C2 - 33925691
AN - SCOPUS:85104721017
SN - 1661-6596
VL - 22
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 9
M1 - 4603
ER -
