Role of abca7 in human health and in alzheimer’s disease

Shiraz Dib, Jens Pahnke, Fabien Gosselet*

*Corresponding author for this work
1 Citation (Scopus)


Several studies, including genome wide association studies (GWAS), have strongly sug-gested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer’s disease (AD). This ABC transporter is now considered as an important genetic deter-minant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.

Original languageEnglish
Article number4603
JournalInternational Journal of Molecular Sciences
Issue number9
Publication statusPublished - 27.04.2021

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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