Abstract
Along with the increasing incidence and favorable prognosis, more women diagnosed with endometrial cancer may develop second primary cancers (SPCs). We aimed at investigating risk of SPCs after endometrial cancer in Germany and Sweden to provide insight into prevention strategies for SPCs. Endometrial cancer patients diagnosed at age ≥15 years in Germany during 1997–2011 and in Sweden nationwide during 1997–2012 were selected. Standardized incidence ratios (SIRs), calculated as the ratio of observed to expected numbers of cases, were used to assess the risk of a specific second cancer after endometrial cancer for both German and Swedish datasets. Among 46,929 endometrial cancer survivors in Germany and 18,646 in Sweden, overall 2,897 and 1,706 SPCs were recorded, respectively. Significantly elevated SIRs were observed in Germany for ovarian (SIR = 1.3; 95%CI:1.1–1.5) and kidney cancers [1.6 (1.3–1.8)], while in Sweden the SIRs were 5.4 (4.6–6.3) and1.4 (1.0–1.9), respectively. Elevated risk for second ovarian endometrioid carcinoma was pronounced after early (<55 years) onset endometrial cancer in Germany [9.0 (4.8–15)] and Sweden [7.7 (5.1–11)]. In Germany elevated risks were found for second ovarian endometrioid carcinoma after endometrioid histology of first endometrial cancer [6.3 (4.0–9.4)] and for second kidney cancer after clear cell histology of endometrial cancer [4.9 (1.6–11)]. We found exceptionally elevated risk of second ovarian endometrioid carcinoma after endometrial cancer of the same histology or of early onset. Risk for second kidney cancer was also increased, particularly after endometrial cancer of clear cell histology. Cancer prevention strategies should focus on these cancers after endometrial cancer diagnosis.
| Original language | English |
|---|---|
| Journal | International Journal of Cancer |
| Volume | 141 |
| Issue number | 11 |
| Pages (from-to) | 2270-2280 |
| Number of pages | 11 |
| ISSN | 0020-7136 |
| DOIs | |
| Publication status | Published - 01.12.2017 |
Funding
Key words: second primary cancer, endometrial cancer, cancer registry, etiology Abbreviations: CI: confidence interval; HNPCC: hereditary non-polyposis colorectal carcinoma; IARC: international agency for research on cancer; ICD-10: international classification of diseases, 10th version; SIRs: standardized incidence ratios; SPCs: second primary cancers Additional Supporting Information may be found in the online version of this article. 1Members of the consortia (GEKID Cancer Survival Working Group) were listed in the Consortia section of our manuscript text. Competing financial interests: None of the authors declared any conflicts of financial interest. Grant sponsor: German Cancer Aid (Deutsche Krebshilfe); Grant number: 108257 and 110446; Grant sponsor: Startup Funds for Advanced Talents at Zhejiang Academy of Medical Sciences; Grant number: ZZ16001; Grant sponsor: Key Research-Development Program of Zhejiang Province; Grant number: 2017C03013; Grant sponsor: Joint Key Program of Zhejiang Province-Ministry of Health; Grant number: WKJ-ZJ-1714; Grant sponsor: Qianjiang Talents Fund of Zhejiang Province; Grant number: QJD1602026; Grant sponsor: Zhejiang Provincial Science and Technology Plan for Research Institutes; Grant number: 2017F10006; Grant sponsor: Foreign Technology and Management Talents Funds from National Bureau of Foreign Experts Affairs; Grant number: 20173300013 DOI: 10.1002/ijc.30930 History: Received 2 June 2017; Accepted 31 July 2017; Online 17 Aug 2017 Correspondence to: Prof. Tianhui Chen, Group of Molecular Epidemiology & Cancer Precision Prevention (GMECPP), Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences (ZJAMS), Tianmushan Road 182,310013, Hangzhou, China, Tel.: [8657188215460], E-mail: [email protected] (or) Dr. Leiting Xu, Ningbo University Medical School, Ningbo, China, Tel.: [8657487600742], E-mail: [email protected]
Research Areas and Centers
- Research Area: Center for Population Medicine and Public Health (ZBV)
