Rise in plasma lactate concentrations with psychosocial stress: A possible sign of cerebral energy demand

Britta Kubera*, Christian Hubold, Saskia Otte, Ann Sophie Lindenberg, Irena Zeiß, Regina Krause, Mirja Steinkamp, Johanna Klement, Sonja Entringer, Luc Pellerin, Achim Peters

*Corresponding author for this work
9 Citations (Scopus)


Objective: It is known that exogenous lactate given as an i.v. energy infusion is able to counteract a neuroglycopenic state that developed during psychosocial stress. It is unknown, however, whether the brain under stressful conditions can induce a rise in plasma lactate to satisfy its increased needs during stress. Since lactate is i) an alternative cerebral energy substrate to glucose and ii) its plasmatic concentration is influenced by the sympathetic nervous system, the present study aimed at investigating whether plasma lactate concentrations increase with psychosocial stress in humans. Methods: 30 healthy young men participated in two sessions (stress induced by the Trier Social Stress Test and a non-stress control session). Blood samples were frequently taken to assess plasma lactate concentrations and stress hormone profiles. Results: Plasma lactate increased 47% during psychosocial stress (from 0.9 ± 0.05 to 1.4 ± 0.1 mmol/l; interaction time × stress intervention: F = 19.7, p < 0.001). This increase in lactate concentrations during stress was associated with an increase in epinephrine (R2 = 0.221, p = 0.02) and ACTH concentrations (R2 = 0.460, p < 0.001). Conclusion: Plasma lactate concentrations increase during acute psychosocial stress in humans. This finding suggests the existence of a demand mechanism that functions to allocate an additional source of energy from the body towards the brain, which we refer to as 'cerebral lactate demand'.

Original languageEnglish
JournalObesity Facts
Issue number3
Pages (from-to)384-392
Number of pages9
Publication statusPublished - 01.06.2012

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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