Rezeptor-mediierter Gentransfer in Plattenepithelkarzinome des Kopf-Hals-Bereiches

Translated title of the contribution: Receptor-mediated gene transfer into head and neck squamous cell cancer

B. Wollenberg*, W. Schmidt, B. Schmitt, S. Lang, R. Zeidler

*Corresponding author for this work
3 Citations (Scopus)


The 'Adeno-Virus-Enhanced-Receptor-Mediated' (AVET)-System uses the receptor-mediated endocytosis route to introduce DNA into mammalian cells. By the help of a replication defective adenovirus with endosomolytic activity the coentry of receptor-bound DNA particles is faciliated. The transport to the nucleus followed by gene expression is multifold enhanced. Methods: Two different permanent cell lines from head and neck squamous cell cancer were transfected with the reporter gene for luciferase with either AVET or different liposoms in vitro. Results: In comparison it becomes obvious, that AVET shows a multifold higher transfection rate in vitro than the liposomal formulations applied. Conclusions: AVET could be used for efficient transfection of epithelial cells, that are fairly reluctant to DNA transfer. Further trials in the mouse model must prove a possible application in vivo.

Translated title of the contributionReceptor-mediated gene transfer into head and neck squamous cell cancer
Original languageGerman
JournalLaryngo- Rhino- Otologie
Issue number7
Pages (from-to)411-414
Number of pages4
Publication statusPublished - 07.1997


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