Abstract
Selective serotonin reuptake inhibitors (SSRIs) are becoming widely used because of their favorable side-effect profile and their safety in overdose. We report about a patient with recurring major depression (DSM-IIIR) who was treated with paroxetine and developed a severe hepatotoxic reaction, which was reversed after withdrawal of the drug. Individual, patient-related causes for this side-effect were not found. To our knowledge, this is the first published case of a probably paroxetine-induced severe hepatotoxicity. Hepatotoxicity should be taken into account as a rare complication that may occur not only with tricyclic antidepressants (TCAs) but also with SSRIs.
Original language | English |
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Journal | Pharmacopsychiatry |
Volume | 29 |
Issue number | 6 |
Pages (from-to) | 223-226 |
Number of pages | 4 |
ISSN | 0176-3679 |
DOIs | |
Publication status | Published - 01.01.1996 |
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)