Results of the prospective multicenter SoLKiD cohort study indicate bio-psycho-social outcome risks to kidney donors 12 months after donation

SoLKiD study group

doi:10.1016/j.kint.2021.12.007

Results of the prospective multicenter SoLKiD cohort study indicate bio-psycho-social outcome risks to kidney donors 12 months after donation

SoLKiD study group

Abstract

The outcome after living kidney donation was assumed to be comparable to that of the general population. However, recent register studies reveal negative changes in kidney function, quality of life and fatigue. Avoiding methodological issues of previous studies, the Safety of the Living Kidney Donor (SoLKiD) cohort study analyzed the outcome of donors in a multicenter and interdisciplinary fashion. Donor data were collected pre-donation and two-, six- and 12-months post-donation in 20 German transplantation centers. Primary parameters were kidney function, quality of life, and fatigue. Secondary endpoints were blood pressure, hemoglobin, hemoglobin A1c, body mass index, depression and somatization. Parameters were analyzed with non-parametric statistical tests and a mixed model regression for changes in time, their clinical relevance and interaction encompassing 336 donors with mean age of 52 years. Most of the physical secondary parameters, depression, and quality of life showed little or no changes and regained their pre-donation level. Kidney function decreased significantly with a 37% loss of glomerular filtration rate and an increase of donors with chronic kidney disease stage 3 from 1.5% pre-donation to about 50%. Donors consistently showed increased fatigue and somatization. Mental fatigue increased from 10.6% to 28.1%. The main influencing factors for decreased kidney function and increased fatigue were their respective pre-donation levels, and donor age for kidney function and subject stress level in fatigue. Thus, our study showed that a significant number of donors developed clinically relevant changes in physical and mental health and emphasizes the urgent need to inform potential donors about these risks.

Original language	English
Journal	Kidney International
Volume	101
Issue number	3
Pages (from-to)	597-606
Number of pages	10
ISSN	0085-2538
DOIs	https://doi.org/10.1016/j.kint.2021.12.007
Publication status	Published - 03.2022

Funding

The authors gratefully acknowledge the financial support of the study, funded by the German Ministry of Education and Research (Bundesministerium für Bildung und Forschung), Berlin, Germany (support code: 01 GY1321 ). The authors gratefully acknowledge the financial support of the study, funded by the German Ministry of Education and Research (Bundesministerium f?r Bildung und Forschung), Berlin, Germany (support code: 01 GY1321). BS, HW, KBe, and MB designed the Safety of the Living Kidney Donor (SoLKiD) study. JWOG, EB, BS, and MB performed statistical analyses and interpretation. BS, MB, and VW comprised the data analysis and writing team and received input from Klemens Budde (Member of the Charite Berlin, SoLKiD Study Group), MK, and the SoLKiD study group. BS and MB were recruiters. MK, SK, RW, LR, CS, MZ, Klemens Budde (Member of the Charite Berlin, SoLKiD Study Group), FH, KI, AH, PR, AP, AM, UF, and RW were the members of the SoLKiD study group. The manuscript was drafted by BS, MB, and JWOG and reviewed by all authors. All authors provided significant intellectual contributions to the manuscript and approved the final and revised version.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.kint.2021.12.007

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@article{eb81a7788608428da07b51b17a33f7f2,

title = "Results of the prospective multicenter SoLKiD cohort study indicate bio-psycho-social outcome risks to kidney donors 12 months after donation",

abstract = "The outcome after living kidney donation was assumed to be comparable to that of the general population. However, recent register studies reveal negative changes in kidney function, quality of life and fatigue. Avoiding methodological issues of previous studies, the Safety of the Living Kidney Donor (SoLKiD) cohort study analyzed the outcome of donors in a multicenter and interdisciplinary fashion. Donor data were collected pre-donation and two-, six- and 12-months post-donation in 20 German transplantation centers. Primary parameters were kidney function, quality of life, and fatigue. Secondary endpoints were blood pressure, hemoglobin, hemoglobin A1c, body mass index, depression and somatization. Parameters were analyzed with non-parametric statistical tests and a mixed model regression for changes in time, their clinical relevance and interaction encompassing 336 donors with mean age of 52 years. Most of the physical secondary parameters, depression, and quality of life showed little or no changes and regained their pre-donation level. Kidney function decreased significantly with a 37\% loss of glomerular filtration rate and an increase of donors with chronic kidney disease stage 3 from 1.5\% pre-donation to about 50\%. Donors consistently showed increased fatigue and somatization. Mental fatigue increased from 10.6\% to 28.1\%. The main influencing factors for decreased kidney function and increased fatigue were their respective pre-donation levels, and donor age for kidney function and subject stress level in fatigue. Thus, our study showed that a significant number of donors developed clinically relevant changes in physical and mental health and emphasizes the urgent need to inform potential donors about these risks.",

author = "\{SoLKiD study group\} and Barbara Suwelack and Klaus Berger and Heiner Wolters and Ger{\ss}, \{Joachim W.O.\} and Eike Bormann and Viktorya W{\"o}rmann and Markus Burgmer and Martina Koch and Sylvia Kr{\"o}ncke and Rolf Weimer and Lucy Rainer and Claudia Sommerer and Martin Zeier and Klemens Budde and Fabian Halleck and Katrin Ivens and Anita Hansen and Petra Reinke and Andreas Pascher and Anja M{\"u}hlfeld and J{\"u}rgen Floege and Roger Wahba and Frank Vitinius and Andreas Kribben and Ute Eisenberger and Christian Hugo and Carmen Quick and Martin Nitschke and Inge Derad and Thomas Rath and Christian M{\"o}nch and Mario Schiffer and Faikal G{\"u}ler and Bernd Kr{\"u}ger and Roderich B{\"o}nnighoff and Ingeborg Hauser and Steffen Platschek and Kai Lopau and Ulrich Pein and Karl Weigand and Thorsten Feldkamp and Ulrich Kunzendorf",

note = "Publisher Copyright: {\textcopyright} 2021 International Society of Nephrology",

year = "2022",

month = mar,

doi = "10.1016/j.kint.2021.12.007",

language = "English",

volume = "101",

pages = "597--606",

journal = "Kidney International",

issn = "0085-2538",

publisher = "Elsevier B.V.",

number = "3",

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TY - JOUR

T1 - Results of the prospective multicenter SoLKiD cohort study indicate bio-psycho-social outcome risks to kidney donors 12 months after donation

AU - SoLKiD study group

AU - Suwelack, Barbara

AU - Berger, Klaus

AU - Wolters, Heiner

AU - Gerß, Joachim W.O.

AU - Bormann, Eike

AU - Wörmann, Viktorya

AU - Burgmer, Markus

AU - Koch, Martina

AU - Kröncke, Sylvia

AU - Weimer, Rolf

AU - Rainer, Lucy

AU - Sommerer, Claudia

AU - Zeier, Martin

AU - Budde, Klemens

AU - Halleck, Fabian

AU - Ivens, Katrin

AU - Hansen, Anita

AU - Reinke, Petra

AU - Pascher, Andreas

AU - Mühlfeld, Anja

AU - Floege, Jürgen

AU - Wahba, Roger

AU - Vitinius, Frank

AU - Kribben, Andreas

AU - Eisenberger, Ute

AU - Hugo, Christian

AU - Quick, Carmen

AU - Nitschke, Martin

AU - Derad, Inge

AU - Rath, Thomas

AU - Mönch, Christian

AU - Schiffer, Mario

AU - Güler, Faikal

AU - Krüger, Bernd

AU - Bönnighoff, Roderich

AU - Hauser, Ingeborg

AU - Platschek, Steffen

AU - Lopau, Kai

AU - Pein, Ulrich

AU - Weigand, Karl

AU - Feldkamp, Thorsten

AU - Kunzendorf, Ulrich

PY - 2022/3

Y1 - 2022/3

N2 - The outcome after living kidney donation was assumed to be comparable to that of the general population. However, recent register studies reveal negative changes in kidney function, quality of life and fatigue. Avoiding methodological issues of previous studies, the Safety of the Living Kidney Donor (SoLKiD) cohort study analyzed the outcome of donors in a multicenter and interdisciplinary fashion. Donor data were collected pre-donation and two-, six- and 12-months post-donation in 20 German transplantation centers. Primary parameters were kidney function, quality of life, and fatigue. Secondary endpoints were blood pressure, hemoglobin, hemoglobin A1c, body mass index, depression and somatization. Parameters were analyzed with non-parametric statistical tests and a mixed model regression for changes in time, their clinical relevance and interaction encompassing 336 donors with mean age of 52 years. Most of the physical secondary parameters, depression, and quality of life showed little or no changes and regained their pre-donation level. Kidney function decreased significantly with a 37% loss of glomerular filtration rate and an increase of donors with chronic kidney disease stage 3 from 1.5% pre-donation to about 50%. Donors consistently showed increased fatigue and somatization. Mental fatigue increased from 10.6% to 28.1%. The main influencing factors for decreased kidney function and increased fatigue were their respective pre-donation levels, and donor age for kidney function and subject stress level in fatigue. Thus, our study showed that a significant number of donors developed clinically relevant changes in physical and mental health and emphasizes the urgent need to inform potential donors about these risks.

AB - The outcome after living kidney donation was assumed to be comparable to that of the general population. However, recent register studies reveal negative changes in kidney function, quality of life and fatigue. Avoiding methodological issues of previous studies, the Safety of the Living Kidney Donor (SoLKiD) cohort study analyzed the outcome of donors in a multicenter and interdisciplinary fashion. Donor data were collected pre-donation and two-, six- and 12-months post-donation in 20 German transplantation centers. Primary parameters were kidney function, quality of life, and fatigue. Secondary endpoints were blood pressure, hemoglobin, hemoglobin A1c, body mass index, depression and somatization. Parameters were analyzed with non-parametric statistical tests and a mixed model regression for changes in time, their clinical relevance and interaction encompassing 336 donors with mean age of 52 years. Most of the physical secondary parameters, depression, and quality of life showed little or no changes and regained their pre-donation level. Kidney function decreased significantly with a 37% loss of glomerular filtration rate and an increase of donors with chronic kidney disease stage 3 from 1.5% pre-donation to about 50%. Donors consistently showed increased fatigue and somatization. Mental fatigue increased from 10.6% to 28.1%. The main influencing factors for decreased kidney function and increased fatigue were their respective pre-donation levels, and donor age for kidney function and subject stress level in fatigue. Thus, our study showed that a significant number of donors developed clinically relevant changes in physical and mental health and emphasizes the urgent need to inform potential donors about these risks.

UR - https://www.scopus.com/pages/publications/85123897105

UR - https://www.mendeley.com/catalogue/57e4ea7a-1bc3-3229-a4c8-03a3c2ef9ddb/

U2 - 10.1016/j.kint.2021.12.007

DO - 10.1016/j.kint.2021.12.007

M3 - Journal articles

C2 - 34953772

AN - SCOPUS:85123897105

SN - 0085-2538

VL - 101

SP - 597

EP - 606

JO - Kidney International

JF - Kidney International

IS - 3

ER -

Results of the prospective multicenter SoLKiD cohort study indicate bio-psycho-social outcome risks to kidney donors 12 months after donation

Abstract

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