Research in practice: Diet and microbiome in autoimmune diseases

Artem Vorobyev; Ralf J. Ludwig

doi:10.1111/ddg.15101

Research in practice: Diet and microbiome in autoimmune diseases

^*Corresponding author for this work

Abstract

The incidence of autoimmune diseases in industrialized countries is constantly increasing over past decades. These diseases lead to increased mortality and persistent reduction in quality of life of the patients, posing a severe medical burden. Treatment of autoimmune diseases is often based on unspecific immune suppression, increasing the risk of infectious diseases as well as cancer manifestation. Pathogenesis of autoimmune conditions is complex and includes not only genetic factors, but also environmental influence, which is considered to be the reason for the rise of incidence of autoimmune diseases. Environmental factors comprise numerous elements, such as infections, smoking, medication, diet etc., which can either promote or prevent the onset of autoimmunity. However, the mechanisms of environmental influence are complex and for this moment not clearly understood. Deciphering of these interactions could enhance our comprehension of autoimmunity and provide some novel treatment options for the patients.

Original language	English
Journal	JDDG - Journal of the German Society of Dermatology
Volume	21
Issue number	9
Pages (from-to)	958-962
Number of pages	5
ISSN	1610-0379
DOIs	https://doi.org/10.1111/ddg.15101
Publication status	Published - 09.2023

Funding

This project was supported by Clinician Scientist Stipend of German Dermatological Society (DDG/ADF), Clusters of Excellence EXC2167 “Precision Medicine in Chronic Inflammation” and EXC306 „Inflammation at Interfaces“ at the University Hospital Schleswig‐Holstein, Campus Lübeck, as well as Research Training Groups “Genes, Environment and Inflammation” (GRK 1743) and “Modulation of Autoimmunity” (GRK 1727). This project was supported by Clinician Scientist Stipend of German Dermatological Society (derma.de), Arbeitsgemeinschaft Dermatologische Forschung (adf-online.de), Deutsche Stiftung für Dermatologie, Clusters of Excellence EXC2167 “Precision Medicine in Chronic Inflammation” and EXC306 „Inflammation at Interfaces“ at the University Hospital Schleswig-Holstein, Campus Lübeck, as well as Research Training Groups “Genes, Environment and Inflammation” (GRK 1743) and “Modulation of Autoimmunity” (GRK 1727). The Clinican Scientist Program of the DDG is kindly supported by: Abbvie Germany, Almirall, Janssen-Cilag, Leo Pharma, Lilly and Novartis. Open access funding enabled and organized by Projekt DEAL.

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)
Centers: Center for Research on Inflammation of the Skin (CRIS)

DFG Research Classification Scheme

2.21-05 Immunology
2.22-19 Dermatology
2.22-22 Clinical Immunology and Allergology
2.22-05 Nutritional Sciences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/ddg.15101

Cite this

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title = "Research in practice: Diet and microbiome in autoimmune diseases",

abstract = "The incidence of autoimmune diseases in industrialized countries is constantly increasing over past decades. These diseases lead to increased mortality and persistent reduction in quality of life of the patients, posing a severe medical burden. Treatment of autoimmune diseases is often based on unspecific immune suppression, increasing the risk of infectious diseases as well as cancer manifestation. Pathogenesis of autoimmune conditions is complex and includes not only genetic factors, but also environmental influence, which is considered to be the reason for the rise of incidence of autoimmune diseases. Environmental factors comprise numerous elements, such as infections, smoking, medication, diet etc., which can either promote or prevent the onset of autoimmunity. However, the mechanisms of environmental influence are complex and for this moment not clearly understood. Deciphering of these interactions could enhance our comprehension of autoimmunity and provide some novel treatment options for the patients.",

author = "Artem Vorobyev and Ludwig, \{Ralf J.\}",

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AB - The incidence of autoimmune diseases in industrialized countries is constantly increasing over past decades. These diseases lead to increased mortality and persistent reduction in quality of life of the patients, posing a severe medical burden. Treatment of autoimmune diseases is often based on unspecific immune suppression, increasing the risk of infectious diseases as well as cancer manifestation. Pathogenesis of autoimmune conditions is complex and includes not only genetic factors, but also environmental influence, which is considered to be the reason for the rise of incidence of autoimmune diseases. Environmental factors comprise numerous elements, such as infections, smoking, medication, diet etc., which can either promote or prevent the onset of autoimmunity. However, the mechanisms of environmental influence are complex and for this moment not clearly understood. Deciphering of these interactions could enhance our comprehension of autoimmunity and provide some novel treatment options for the patients.

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Research in practice: Diet and microbiome in autoimmune diseases

Abstract

Funding

Research Areas and Centers

DFG Research Classification Scheme

UN SDGs

Access to Document

Other files and links

Fingerprint

CRC 1526, PANTAU: Pathomechanisms of Antibody-mediated Autoimmunity

Cite this

Research in practice: Diet and microbiome in autoimmune diseases

Abstract

Funding

Research Areas and Centers

DFG Research Classification Scheme

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

CRC 1526, PANTAU: Pathomechanisms of Antibody-mediated Autoimmunity

Cite this