Renal denervation improves 24-hour central and peripheral blood pressures, arterial stiffness, and peripheral resistance

Christian Ott, Klaas F. Franzen, Tobias Graf, Joachim Weil, Roland E. Schmieder, Michael Reppel, Kai Mortensen*

*Corresponding author for this work
5 Citations (Scopus)

Abstract

Ambulatory blood pressure (BP) and central BP are better predictors for overall cardiovascular risk and mortality than brachial BP. Renal denervation (RDN) has been shown to reduce office brachial and central BP as well as brachial ambulatory BP, but data on central ambulatory BP are limited. Patients (N = 94) with treatment resistant hypertension (TRH) who underwent RDN were included. Ambulatory BP, including central pressures, hemodynamics, and arterial stiffness were measured at baseline and 3, 6, 12 months after RDN by an oscillometric device (MobiloGraph). At 3, 6, and 12-month follow-ups, brachial ambulatory BP was reduced (P for all <.001). Consistently, central ambulatory BP was reduced (P for all <.001). Ambulatory assessed averaged daytime pulse wave velocity improved after RDN (P <.05). Total vascular resistance decreased (P for all <.01). In patients with TRH, RDN improves brachial and central ambulatory BP, arterial stiffness, and total vascular resistance, indicating an improvement of cardiovascular outcome.

Original languageEnglish
JournalJournal of Clinical Hypertension
Volume20
Issue number2
Pages (from-to)366-372
Number of pages7
ISSN1524-6175
DOIs
Publication statusPublished - 01.02.2018

Research Areas and Centers

  • Centers: Cardiological Center Luebeck (UHZL)

DFG Research Classification Scheme

  • 205-12 Cardiology, Angiology

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