Relation of cerebral blood flow velocity and level of vigilance in humans

Cornelia Schnittger; Sönke Johannes; Anouscheh Arnavaz; Thomas F. Münte

doi:10.1097/00001756-199705060-00016

Relation of cerebral blood flow velocity and level of vigilance in humans

Cornelia Schnittger, Sönke Johannes, Anouscheh Arnavaz, Thomas F. Münte^*

^*Corresponding author for this work

Clinic of Neurology

24 Citations (Scopus)

Abstract

Blood flow velocities in both middle cerebral arteries (MCA) were measured using transcranial Doppler ultrasound (TCD) in healthy subjects engaged in a continuous static visual vigilance task. Stimuli comprised white vertical gratings on a black background with a size of 5 x 5°(non-targets) or 5 x 3.5°(targets). Button presses were required to the rare (8.5%) targets. Over the 30 min session a decrease in hit rate and an increase in reaction time were seen, indicating a decrease in vigilance. These performance changes were paralleled by a decrease in flow velocity in both MCAs. No hemispheric difference was seen. These data suggest a close coupling of performance and blood flow in vigilance tasks. Modulation of cholinergic activity during the vigilance task might be the common underlying mechanism.

Original language	English
Journal	NeuroReport
Volume	8
Issue number	7
Pages (from-to)	1637-1639
Number of pages	3
ISSN	0959-4965
DOIs	https://doi.org/10.1097/00001756-199705060-00016
Publication status	Published - 01.01.1997

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1097/00001756-199705060-00016

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AU - Schnittger, Cornelia

AU - Johannes, Sönke

AU - Arnavaz, Anouscheh

AU - Münte, Thomas F.

PY - 1997/1/1

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N2 - Blood flow velocities in both middle cerebral arteries (MCA) were measured using transcranial Doppler ultrasound (TCD) in healthy subjects engaged in a continuous static visual vigilance task. Stimuli comprised white vertical gratings on a black background with a size of 5 x 5°(non-targets) or 5 x 3.5°(targets). Button presses were required to the rare (8.5%) targets. Over the 30 min session a decrease in hit rate and an increase in reaction time were seen, indicating a decrease in vigilance. These performance changes were paralleled by a decrease in flow velocity in both MCAs. No hemispheric difference was seen. These data suggest a close coupling of performance and blood flow in vigilance tasks. Modulation of cholinergic activity during the vigilance task might be the common underlying mechanism.

AB - Blood flow velocities in both middle cerebral arteries (MCA) were measured using transcranial Doppler ultrasound (TCD) in healthy subjects engaged in a continuous static visual vigilance task. Stimuli comprised white vertical gratings on a black background with a size of 5 x 5°(non-targets) or 5 x 3.5°(targets). Button presses were required to the rare (8.5%) targets. Over the 30 min session a decrease in hit rate and an increase in reaction time were seen, indicating a decrease in vigilance. These performance changes were paralleled by a decrease in flow velocity in both MCAs. No hemispheric difference was seen. These data suggest a close coupling of performance and blood flow in vigilance tasks. Modulation of cholinergic activity during the vigilance task might be the common underlying mechanism.

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Relation of cerebral blood flow velocity and level of vigilance in humans

Abstract

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