Regulation of microRNAs and their role in liver development, regeneration and disease

Megan L. Finch; Jens U. Marquardt; George C. Yeoh; Bernard A. Callus

doi:10.1016/j.biocel.2014.04.002

Regulation of microRNAs and their role in liver development, regeneration and disease

Megan L. Finch, Jens U. Marquardt, George C. Yeoh, Bernard A. Callus^*

^*Corresponding author for this work

Clinic of Internal Medicine I

University of Western Australia

61 Citations (Scopus)

Abstract

Since their discovery more than a decade ago microRNAs have been demonstrated to have profound effects on almost every aspect of biology. Numerous studies in recent years have shown that microRNAs have important roles in development and in the etiology and progression of disease. This review is focused on microRNAs and the roles they play in liver development, regeneration and liver disease; particularly chronic liver diseases such as alcoholic liver disease, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, viral hepatitis and primary liver cancer. The key microRNAs identified in liver development and chronic liver disease will be discussed together with, where possible, the target messenger RNAs that these microRNAs regulate to profoundly alter these processes. This article is part of a Directed Issue entitled: The Non-coding RNA Revolution.

Original language	English
Journal	International Journal of Biochemistry and Cell Biology
Volume	54
Pages (from-to)	288-303
Number of pages	16
ISSN	1357-2725
DOIs	https://doi.org/10.1016/j.biocel.2014.04.002
Publication status	Published - 09.2014

Funding

BAC is a Research Fellow of the Cancer Council of Western Australia (CCWA). This work was supported by funding from the Association of International Cancer Research (No. 09-0084 ) and the CCWA (Nos. APP1010749 and APP1067515 ) to BAC and from the CCWA (No. 1030183 ) and the NHMRC of Australia (Nos. APP1023187 , APP1022498 and APP1042368 ) to GCY.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.biocel.2014.04.002

Cite this

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abstract = "Since their discovery more than a decade ago microRNAs have been demonstrated to have profound effects on almost every aspect of biology. Numerous studies in recent years have shown that microRNAs have important roles in development and in the etiology and progression of disease. This review is focused on microRNAs and the roles they play in liver development, regeneration and liver disease; particularly chronic liver diseases such as alcoholic liver disease, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, viral hepatitis and primary liver cancer. The key microRNAs identified in liver development and chronic liver disease will be discussed together with, where possible, the target messenger RNAs that these microRNAs regulate to profoundly alter these processes. This article is part of a Directed Issue entitled: The Non-coding RNA Revolution.",

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AB - Since their discovery more than a decade ago microRNAs have been demonstrated to have profound effects on almost every aspect of biology. Numerous studies in recent years have shown that microRNAs have important roles in development and in the etiology and progression of disease. This review is focused on microRNAs and the roles they play in liver development, regeneration and liver disease; particularly chronic liver diseases such as alcoholic liver disease, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, viral hepatitis and primary liver cancer. The key microRNAs identified in liver development and chronic liver disease will be discussed together with, where possible, the target messenger RNAs that these microRNAs regulate to profoundly alter these processes. This article is part of a Directed Issue entitled: The Non-coding RNA Revolution.

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Regulation of microRNAs and their role in liver development, regeneration and disease

Abstract

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UN SDGs

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