TY - JOUR
T1 - Regulation of epithelial-mesenchymal plasticity in pancreatic ductal adenocarcinoma
T2 - Role of key molecules in tumor differentiation and therapy
AU - Ling, Qi
AU - Ong, Meiching
AU - Konukiewitz, Björn
AU - Braun, Rüdiger
AU - Marquardt, Jens Uwe
AU - Lehnert, Hendrik
AU - Kalthoff, Holger
AU - Ungefroren, Hendrik
N1 - Publisher Copyright:
© 2025 Elsevier Ltd
PY - 2025/7/25
Y1 - 2025/7/25
N2 - Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers, with most patients diagnosed at advanced stages. Therefore, understanding tumor development and improving treatment strategies is critical. Tumor cell plasticity enables differentiation, de-differentiation, and trans-differentiation, processes regulated by EMT and MET. These transitions are often controlled by structurally similar but functionally opposing protein pairs, including alternatively spliced isoforms (RAC1/RAC1B or TAp73α/TAp73β), phosphorylated vs. unphosphorylated forms of the same protein (SMAD3), or ligand source (paracrine vs. autocrine TGF-β1). These proteins modulate canonical and non-canonical TGF-β signaling or function as its effectors. This review explores their roles in epithelial signaling and differentiation, aiming to inform novel targeted and personalized PDAC therapies.
AB - Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers, with most patients diagnosed at advanced stages. Therefore, understanding tumor development and improving treatment strategies is critical. Tumor cell plasticity enables differentiation, de-differentiation, and trans-differentiation, processes regulated by EMT and MET. These transitions are often controlled by structurally similar but functionally opposing protein pairs, including alternatively spliced isoforms (RAC1/RAC1B or TAp73α/TAp73β), phosphorylated vs. unphosphorylated forms of the same protein (SMAD3), or ligand source (paracrine vs. autocrine TGF-β1). These proteins modulate canonical and non-canonical TGF-β signaling or function as its effectors. This review explores their roles in epithelial signaling and differentiation, aiming to inform novel targeted and personalized PDAC therapies.
UR - http://www.scopus.com/inward/record.url?scp=105007813422&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/9039d296-b581-3ed6-9cd6-ff707540c531/
U2 - 10.1016/j.ejca.2025.115561
DO - 10.1016/j.ejca.2025.115561
M3 - Scientific review articles
AN - SCOPUS:105007813422
SN - 0959-8049
VL - 225
JO - European Journal of Cancer
JF - European Journal of Cancer
M1 - 115561
ER -
