TY - JOUR
T1 - Regional vulnerability of mesencephalic dopaminergic neurons prone to degenerate in Parkinson's disease: A post-mortem study in human control subjects
AU - Lu, Lixia
AU - Neff, Frauke
AU - Fischer, Daniel Alvarez
AU - Henze, Carmen
AU - Hirsch, Etienne C.
AU - Oertel, Wolfgang H.
AU - Schlegel, Jürgen
AU - Hartmann, Andreas
PY - 2006/8/1
Y1 - 2006/8/1
N2 - Parkinson's disease (PD) is characterized by loss of dopaminergic (DA) neurons in the human midbrain, which varies greatly among mesencephalic subregions. The genetic expression profiles of mesencephalic DA neurons particularly prone to degenerate during PD (nigrosome 1 within the substantia nigra pars compacta-SNpc) and those particularly resistant in the disease course (central grey substance-CGS) were compared in five control subjects by immuno-laser capture microdissection followed by RNA arbitrarily primed PCR. 8 ESTs of interest were selected for analysis by real time quantitative reverse transcription PCR. DA neurons in the CGS preferentially expressed implicated in cell survival (7 out of 8 genes selected), whereas SNpc DA neurons preferentially expressed one gene making them potentially susceptible to undergo cell death in PD. We propose that factors making CGS DA neurons more resistant may be helpful in protecting SNpc DA neurons against a pathological insult.
AB - Parkinson's disease (PD) is characterized by loss of dopaminergic (DA) neurons in the human midbrain, which varies greatly among mesencephalic subregions. The genetic expression profiles of mesencephalic DA neurons particularly prone to degenerate during PD (nigrosome 1 within the substantia nigra pars compacta-SNpc) and those particularly resistant in the disease course (central grey substance-CGS) were compared in five control subjects by immuno-laser capture microdissection followed by RNA arbitrarily primed PCR. 8 ESTs of interest were selected for analysis by real time quantitative reverse transcription PCR. DA neurons in the CGS preferentially expressed implicated in cell survival (7 out of 8 genes selected), whereas SNpc DA neurons preferentially expressed one gene making them potentially susceptible to undergo cell death in PD. We propose that factors making CGS DA neurons more resistant may be helpful in protecting SNpc DA neurons against a pathological insult.
UR - http://www.scopus.com/inward/record.url?scp=33746104035&partnerID=8YFLogxK
U2 - 10.1016/j.nbd.2006.04.002
DO - 10.1016/j.nbd.2006.04.002
M3 - Journal articles
C2 - 16753304
AN - SCOPUS:33746104035
SN - 0969-9961
VL - 23
SP - 409
EP - 421
JO - Neurobiology of Disease
JF - Neurobiology of Disease
IS - 2
ER -
