Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y2 receptor activation

Heike Nave; Sammy Bedoui; Frank Moenter; Jan Steffens; Melanie Felies; Thomas Gebhardt; Rainer H. Straub; Reinhard Pabst; Mira Dimitrijevic; Stanislava Stanojevic; Stephan Von Hörsten

doi:10.1016/j.jneuroim.2004.05.009

Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y₂ receptor activation

Heike Nave^*, Sammy Bedoui, Frank Moenter, Jan Steffens, Melanie Felies, Thomas Gebhardt, Rainer H. Straub, Reinhard Pabst, Mira Dimitrijevic, Stanislava Stanojevic, Stephan Von Hörsten

^*Corresponding author for this work

51 Citations (Scopus)

Abstract

Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y₂ receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions.

Original language	English
Journal	Journal of Neuroimmunology
Volume	155
Issue number	1-2
Pages (from-to)	1-12
Number of pages	12
ISSN	0165-5728
DOIs	https://doi.org/10.1016/j.jneuroim.2004.05.009
Publication status	Published - 01.10.2004
Externally published	Yes

Funding

The excellent technical assistance of S. Kuhlmann and I. Dressendörfer is very much appreciated. The correction of the English by S. Fryk is gratefully acknowledged. This work was supported by a grant from the Volkswagen Foundation (/I/75169).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 10 Reduced Inequalities

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

Access to Document

10.1016/j.jneuroim.2004.05.009

Cite this

Nave, H., Bedoui, S., Moenter, F., Steffens, J., Felies, M., Gebhardt, T., Straub, R. H., Pabst, R., Dimitrijevic, M., Stanojevic, S., & Von Hörsten, S. (2004). Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y₂ receptor activation. Journal of Neuroimmunology, 155(1-2), 1-12. https://doi.org/10.1016/j.jneuroim.2004.05.009

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title = "Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y2 receptor activation",

abstract = "Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y2 receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions.",

author = "Heike Nave and Sammy Bedoui and Frank Moenter and Jan Steffens and Melanie Felies and Thomas Gebhardt and Straub, \{Rainer H.\} and Reinhard Pabst and Mira Dimitrijevic and Stanislava Stanojevic and \{Von H{\"o}rsten\}, Stephan",

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Nave, H, Bedoui, S, Moenter, F, Steffens, J, Felies, M, Gebhardt, T, Straub, RH, Pabst, R, Dimitrijevic, M, Stanojevic, S & Von Hörsten, S 2004, 'Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y₂ receptor activation', Journal of Neuroimmunology, vol. 155, no. 1-2, pp. 1-12. https://doi.org/10.1016/j.jneuroim.2004.05.009

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T1 - Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y2 receptor activation

AU - Nave, Heike

AU - Bedoui, Sammy

AU - Moenter, Frank

AU - Steffens, Jan

AU - Felies, Melanie

AU - Gebhardt, Thomas

AU - Straub, Rainer H.

AU - Pabst, Reinhard

AU - Dimitrijevic, Mira

AU - Stanojevic, Stanislava

AU - Von Hörsten, Stephan

PY - 2004/10/1

Y1 - 2004/10/1

N2 - Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y2 receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions.

AB - Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y2 receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions.

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