Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y2 receptor activation

Heike Nave; Sammy Bedoui; Frank Moenter; Jan Steffens; Melanie Felies; Thomas Gebhardt; Rainer H. Straub; Reinhard Pabst; Mira Dimitrijevic; Stanislava Stanojevic; Stephan Von Hörsten

doi:10.1016/j.jneuroim.2004.05.009

Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y₂ receptor activation

Heike Nave^*, Sammy Bedoui, Frank Moenter, Jan Steffens, Melanie Felies, Thomas Gebhardt, Rainer H. Straub, Reinhard Pabst, Mira Dimitrijevic, Stanislava Stanojevic, Stephan Von Hörsten

^*Corresponding author for this work

41 Citations (Scopus)

Abstract

Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y₂ receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions.

Original language	English
Journal	Journal of Neuroimmunology
Volume	155
Issue number	1-2
Pages (from-to)	1-12
Number of pages	12
ISSN	0165-5728
DOIs	https://doi.org/10.1016/j.jneuroim.2004.05.009
Publication status	Published - 01.10.2004
Externally published	Yes

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jneuroim.2004.05.009

Cite this

Nave, H., Bedoui, S., Moenter, F., Steffens, J., Felies, M., Gebhardt, T., Straub, R. H., Pabst, R., Dimitrijevic, M., Stanojevic, S., & Von Hörsten, S. (2004). Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y₂ receptor activation. Journal of Neuroimmunology, 155(1-2), 1-12. https://doi.org/10.1016/j.jneuroim.2004.05.009

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title = "Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y2 receptor activation",

abstract = "Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y2 receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions.",

author = "Heike Nave and Sammy Bedoui and Frank Moenter and Jan Steffens and Melanie Felies and Thomas Gebhardt and Straub, {Rainer H.} and Reinhard Pabst and Mira Dimitrijevic and Stanislava Stanojevic and {Von H{\"o}rsten}, Stephan",

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Nave, H, Bedoui, S, Moenter, F, Steffens, J, Felies, M, Gebhardt, T, Straub, RH, Pabst, R, Dimitrijevic, M, Stanojevic, S & Von Hörsten, S 2004, 'Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y₂ receptor activation', Journal of Neuroimmunology, vol. 155, no. 1-2, pp. 1-12. https://doi.org/10.1016/j.jneuroim.2004.05.009

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T1 - Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y2 receptor activation

AU - Nave, Heike

AU - Bedoui, Sammy

AU - Moenter, Frank

AU - Steffens, Jan

AU - Felies, Melanie

AU - Gebhardt, Thomas

AU - Straub, Rainer H.

AU - Pabst, Reinhard

AU - Dimitrijevic, Mira

AU - Stanojevic, Stanislava

AU - Von Hörsten, Stephan

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AB - Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y2 receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions.

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