Reduced memory B cells in patients with hyper IgE syndrome

C. Speckmann; A. Enders; C. Woellner; D. Thiel; A. Rensing-Ehl; M. Schlesier; J. Rohr; T. Jakob; E. Oswald; M. V. Kopp; O. Sanal; J. Litzman; A. Plebani; M. C. Pietrogrande; J. L. Franco; T. Espanol; B. Grimbacher; S. Ehl

doi:10.1016/j.clim.2008.08.002

Reduced memory B cells in patients with hyper IgE syndrome

C. Speckmann, A. Enders, C. Woellner, D. Thiel, A. Rensing-Ehl, M. Schlesier, J. Rohr, T. Jakob, E. Oswald, M. V. Kopp, O. Sanal, J. Litzman, A. Plebani, M. C. Pietrogrande, J. L. Franco, T. Espanol, B. Grimbacher, S. Ehl^*

^*Corresponding author for this work

Clinic of Pediatric and Adolescent Medicine

52 Citations (Scopus)

Abstract

Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these B cell populations was found in 16 atopic dermatitis patients with IgE levels above 1000 KU/L. There was no correlation between the reduction of memory B cells and the ability to produce specific antibodies. Moreover, there was no correlation between the percentage of memory B cells and the infection history. Analysis of memory B cells can be useful in distinguishing patients with suspected HIES from patients with atopic disease, but probably fails to identify patients who are at high risk of infection.

Original language	English
Journal	Clinical Immunology
Volume	129
Issue number	3
Pages (from-to)	448-454
Number of pages	7
ISSN	1521-6616
DOIs	https://doi.org/10.1016/j.clim.2008.08.002
Publication status	Published - 12.2008

Funding

S.E. is supported by the SFB620 (Project A4). J.L.F. is supported by the Grant colciencias 1115-04-12014. B.G. is supported by DFG grant GR1617/3 and the European Union grants SP23-CT-2005-0064110 and MEXT-CT-2006-042316.

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clim.2008.08.002

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Speckmann, C., Enders, A., Woellner, C., Thiel, D., Rensing-Ehl, A., Schlesier, M., Rohr, J., Jakob, T., Oswald, E., Kopp, M. V., Sanal, O., Litzman, J., Plebani, A., Pietrogrande, M. C., Franco, J. L., Espanol, T., Grimbacher, B., & Ehl, S. (2008). Reduced memory B cells in patients with hyper IgE syndrome. Clinical Immunology, 129(3), 448-454. https://doi.org/10.1016/j.clim.2008.08.002

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title = "Reduced memory B cells in patients with hyper IgE syndrome",

abstract = "Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these B cell populations was found in 16 atopic dermatitis patients with IgE levels above 1000 KU/L. There was no correlation between the reduction of memory B cells and the ability to produce specific antibodies. Moreover, there was no correlation between the percentage of memory B cells and the infection history. Analysis of memory B cells can be useful in distinguishing patients with suspected HIES from patients with atopic disease, but probably fails to identify patients who are at high risk of infection.",

author = "C. Speckmann and A. Enders and C. Woellner and D. Thiel and A. Rensing-Ehl and M. Schlesier and J. Rohr and T. Jakob and E. Oswald and Kopp, {M. V.} and O. Sanal and J. Litzman and A. Plebani and Pietrogrande, {M. C.} and Franco, {J. L.} and T. Espanol and B. Grimbacher and S. Ehl",

note = "Funding Information: S.E. is supported by the SFB620 (Project A4). J.L.F. is supported by the Grant colciencias 1115-04-12014. B.G. is supported by DFG grant GR1617/3 and the European Union grants SP23-CT-2005-0064110 and MEXT-CT-2006-042316. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.",

year = "2008",

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doi = "10.1016/j.clim.2008.08.002",

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Speckmann, C, Enders, A, Woellner, C, Thiel, D, Rensing-Ehl, A, Schlesier, M, Rohr, J, Jakob, T, Oswald, E, Kopp, MV, Sanal, O, Litzman, J, Plebani, A, Pietrogrande, MC, Franco, JL, Espanol, T, Grimbacher, B & Ehl, S 2008, 'Reduced memory B cells in patients with hyper IgE syndrome', Clinical Immunology, vol. 129, no. 3, pp. 448-454. https://doi.org/10.1016/j.clim.2008.08.002

TY - JOUR

T1 - Reduced memory B cells in patients with hyper IgE syndrome

AU - Speckmann, C.

AU - Enders, A.

AU - Woellner, C.

AU - Thiel, D.

AU - Rensing-Ehl, A.

AU - Schlesier, M.

AU - Rohr, J.

AU - Jakob, T.

AU - Oswald, E.

AU - Kopp, M. V.

AU - Sanal, O.

AU - Litzman, J.

AU - Plebani, A.

AU - Pietrogrande, M. C.

AU - Franco, J. L.

AU - Espanol, T.

AU - Grimbacher, B.

AU - Ehl, S.

N1 - Funding Information: S.E. is supported by the SFB620 (Project A4). J.L.F. is supported by the Grant colciencias 1115-04-12014. B.G. is supported by DFG grant GR1617/3 and the European Union grants SP23-CT-2005-0064110 and MEXT-CT-2006-042316. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.

PY - 2008/12

Y1 - 2008/12

N2 - Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these B cell populations was found in 16 atopic dermatitis patients with IgE levels above 1000 KU/L. There was no correlation between the reduction of memory B cells and the ability to produce specific antibodies. Moreover, there was no correlation between the percentage of memory B cells and the infection history. Analysis of memory B cells can be useful in distinguishing patients with suspected HIES from patients with atopic disease, but probably fails to identify patients who are at high risk of infection.

AB - Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these B cell populations was found in 16 atopic dermatitis patients with IgE levels above 1000 KU/L. There was no correlation between the reduction of memory B cells and the ability to produce specific antibodies. Moreover, there was no correlation between the percentage of memory B cells and the infection history. Analysis of memory B cells can be useful in distinguishing patients with suspected HIES from patients with atopic disease, but probably fails to identify patients who are at high risk of infection.

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ER -

Reduced memory B cells in patients with hyper IgE syndrome

Abstract

Funding

Research Areas and Centers

UN SDGs

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