Reduced IL-10 production and -receptor expression in neonatal T lymphocytes

C. Schultz*, T. Strunk, P. Temming, N. Matzke, C. Härtel

*Corresponding author for this work
23 Citations (Scopus)


Aim: To further evaluate the underlying mechanism of a formerly demonstrated immature anti-inflammatory response in neonates (1). Methods: Interleukin (IL)-10 production was measured by enzyme-linked immunosorbent-assay (ELISA) after anti-CD3/anti-CD28 costimulation of neonatal and adult T cells. IL-10 receptor expression on T lymphocytes, B lymphocytes and monocytes were analysed by flow cytometry in neonates and adult controls. Results: After anti-CD3/anti-CD28 costimulation, IL-10 production of neonatal T lymphocytes was profoundly reduced (median 247 pg/mL vs. 1062 pg/mL, p < 0.0001). IL-10 receptor expression was diminished on neonatal T lymphocytes compared to adults (3% vs. 39.5% IL-10 receptor positive lymphocytes; p < 0.0001). On neonatal B lymphocytes and monocytes the IL-10 receptor expression was comparable to adult controls. Conclusion: The strongly reduced IL-10 receptor expression on the main immune regulative T lymphocytes in conjunction with a significantly impaired synthesis of IL-10 may play a crucial role in the formerly demonstrated deficient anti-inflammatory immune response in neonates.

Original languageEnglish
JournalActa Paediatrica, International Journal of Paediatrics
Issue number8
Pages (from-to)1122-1125
Number of pages4
Publication statusPublished - 08.2007

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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