TY - JOUR
T1 - Recommendations for detection of individual risk for comorbidities in patients with psoriasis
AU - Wohlrab, Johannes
AU - Fiedler, Gabriele
AU - Gerdes, Sascha
AU - Nast, Alexander
AU - Philipp, Sandra
AU - Radtke, Marc A.
AU - Thaçi, Diamant
AU - Koenig, Wolfgang
AU - Pfeiffer, Andreas F.H.
AU - Härter, Martin
AU - Schön, Michael P.
PY - 2013/3
Y1 - 2013/3
N2 - Since the pathogenesis of psoriasis vulgaris is now understood as a T cell mediated systemic auto-immune disease, the awareness for the potential systemic implications of the chronic active inflammation has grown. By evaluation of patient registries and study data, several complexes of comorbidities could be identified in recent years, albeit not all of them being clinically relevant. Comorbidity in this context will be defined as two or more diagnostically distinguished medical conditions existing simultaneously, but without a causal link. Nevertheless, there is some strong indication for pathogenetic link between some specified comorbidities and psoriasis at molecular and immunological level. The need for an interdisciplinary assessment of the potential interrelation is obvious. In order to detect the individual risk for comorbidities in patients with moderate to severe psoriasis and to recommend the course of action, a checklist has been developed at an interdisciplinary level that is reduced to the quintessential points for the use in daily practice.
AB - Since the pathogenesis of psoriasis vulgaris is now understood as a T cell mediated systemic auto-immune disease, the awareness for the potential systemic implications of the chronic active inflammation has grown. By evaluation of patient registries and study data, several complexes of comorbidities could be identified in recent years, albeit not all of them being clinically relevant. Comorbidity in this context will be defined as two or more diagnostically distinguished medical conditions existing simultaneously, but without a causal link. Nevertheless, there is some strong indication for pathogenetic link between some specified comorbidities and psoriasis at molecular and immunological level. The need for an interdisciplinary assessment of the potential interrelation is obvious. In order to detect the individual risk for comorbidities in patients with moderate to severe psoriasis and to recommend the course of action, a checklist has been developed at an interdisciplinary level that is reduced to the quintessential points for the use in daily practice.
UR - http://www.scopus.com/inward/record.url?scp=84878871883&partnerID=8YFLogxK
U2 - 10.1007/s00403-013-1318-9
DO - 10.1007/s00403-013-1318-9
M3 - Scientific review articles
C2 - 23377136
AN - SCOPUS:84878871883
SN - 0340-3696
VL - 305
SP - 91
EP - 98
JO - Archives of Dermatological Research
JF - Archives of Dermatological Research
IS - 2
ER -