Recognition of autologous and allogeneic lymphocytes and tumor cells by human natural killer cells

M. Benczur; G. Sármay; T. Laskay; E. Gyódi; G. Gy Petrányi; J. Gergely

doi:10.1016/0161-5890(82)90301-7

Recognition of autologous and allogeneic lymphocytes and tumor cells by human natural killer cells

M. Benczur^*, G. Sármay, T. Laskay, E. Gyódi, G. Gy Petrányi, J. Gergely

^*Corresponding author for this work

Clinic of Infectious Diseases and Microbiology

3 Citations (Scopus)

Abstract

The shedding of the mobile Fc receptor (FcR₁) and the depletion of the immobile Fc receptor (FcR₁₁) bearing human lymphocytes revealed that human natural killer cells belong to the FcR₁₁-bearing population. Anti-beta-2-microglobulin treatment of the effector cells decreased natural cytotoxicity against some target cells and the detectability of H LA antigens, indicating that histocompatibility antigens or related structures may be involved in natural cytotoxicity. Using a panel of 29 autologous and allogenic PHA-stimulated target cells and peripheral lymphocytes from the same donors as the effector cells, distinct cytotoxic responses against allogeneic and autologous target cells were observed. A computer analysis of selective natural cytotoxicity distinguished seven different groups of target cells that may represent common structures for NK. recognition.

Original language	English
Journal	Molecular Immunology
Volume	19
Issue number	10
Pages (from-to)	1331-1340
Number of pages	10
ISSN	0161-5890
DOIs	https://doi.org/10.1016/0161-5890(82)90301-7
Publication status	Published - 01.01.1982

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Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1016/0161-5890(82)90301-7

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title = "Recognition of autologous and allogeneic lymphocytes and tumor cells by human natural killer cells",

abstract = "The shedding of the mobile Fc receptor (FcR1) and the depletion of the immobile Fc receptor (FcR11) bearing human lymphocytes revealed that human natural killer cells belong to the FcR11-bearing population. Anti-beta-2-microglobulin treatment of the effector cells decreased natural cytotoxicity against some target cells and the detectability of H LA antigens, indicating that histocompatibility antigens or related structures may be involved in natural cytotoxicity. Using a panel of 29 autologous and allogenic PHA-stimulated target cells and peripheral lymphocytes from the same donors as the effector cells, distinct cytotoxic responses against allogeneic and autologous target cells were observed. A computer analysis of selective natural cytotoxicity distinguished seven different groups of target cells that may represent common structures for NK. recognition.",

author = "M. Benczur and G. S{\'a}rmay and T. Laskay and E. Gy{\'o}di and Petr{\'a}nyi, {G. Gy} and J. Gergely",

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T1 - Recognition of autologous and allogeneic lymphocytes and tumor cells by human natural killer cells

AU - Benczur, M.

AU - Sármay, G.

AU - Laskay, T.

AU - Gyódi, E.

AU - Petrányi, G. Gy

AU - Gergely, J.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - The shedding of the mobile Fc receptor (FcR1) and the depletion of the immobile Fc receptor (FcR11) bearing human lymphocytes revealed that human natural killer cells belong to the FcR11-bearing population. Anti-beta-2-microglobulin treatment of the effector cells decreased natural cytotoxicity against some target cells and the detectability of H LA antigens, indicating that histocompatibility antigens or related structures may be involved in natural cytotoxicity. Using a panel of 29 autologous and allogenic PHA-stimulated target cells and peripheral lymphocytes from the same donors as the effector cells, distinct cytotoxic responses against allogeneic and autologous target cells were observed. A computer analysis of selective natural cytotoxicity distinguished seven different groups of target cells that may represent common structures for NK. recognition.

AB - The shedding of the mobile Fc receptor (FcR1) and the depletion of the immobile Fc receptor (FcR11) bearing human lymphocytes revealed that human natural killer cells belong to the FcR11-bearing population. Anti-beta-2-microglobulin treatment of the effector cells decreased natural cytotoxicity against some target cells and the detectability of H LA antigens, indicating that histocompatibility antigens or related structures may be involved in natural cytotoxicity. Using a panel of 29 autologous and allogenic PHA-stimulated target cells and peripheral lymphocytes from the same donors as the effector cells, distinct cytotoxic responses against allogeneic and autologous target cells were observed. A computer analysis of selective natural cytotoxicity distinguished seven different groups of target cells that may represent common structures for NK. recognition.

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Recognition of autologous and allogeneic lymphocytes and tumor cells by human natural killer cells

Abstract

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