Real-world clinical experience with the percutaneous extracorporeal life support system: Results from the German Lifebridge ® Registry

Maryna Masyuk, Peter Abel, Martin Hug, Bernhard Wernly, Assad Haneya, Stefan Sack, Konstantinos Sideris, Nicolas Langwieser, Tobias Graf, Georg Fuernau, Marcus Franz, Ralf Westenfeld, Malte Kelm, Stephan B. Felix, Christian Jung*

*Corresponding author for this work


Background: The concept of percutaneous extracorporeal life support (ECLS) is based on immediate cardiovascular stabilization allowing for sufficient end-organ perfusion, thus improving the outcome in patients with circulatory arrest. Lifebridge ® (Zoll Medical GmbH, Germany) is a portable ECLS device designed for rapid application due to its automated set-up. Methods: A total of 60 tertiary cardiovascular centers were interrogated with regard to application and short-term results after use of Lifebridge ECLS system. Detailed data were collected by standardized case report forms in all centers consented to participate in the study. Demographic and clinical baseline characteristics of the patient population, procedural and follow-up data were recorded and analyzed. Results: In total, 444 patients were analyzed regarding mortality. The detailed study cohort consisted of 112 patients. A total of 80% of the study subjects represented patients post cardiopulmonary resuscitation, 43% were in cardiogenic shock and 50% suffered from acute myocardial infarction. The survival rates were 36% immediately after device implementation and 16% after 30 days. Multivariable analysis revealed that only serum lactate concentration at admission could be proven as independent predictor of patients’ outcome. Patients with lactate concentrations above 10 mmol/L exhibited > 95% mortality (p < 0.05 versus below 10 mmol/L). Conclusion: The present study provides real-world clinical data of patients treated with a transportable automated ECLS system. In conclusion, Lifebridge is a safely applicable cardiorespiratory stabilization tool associated with acceptable complication rates. Nevertheless, mortality rates were high in these critically ill patients, especially in those showing high lactate concentrations at admission.

Original languageEnglish
JournalClinical Research in Cardiology
Publication statusPublished - 01.01.2019

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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