Re-evaluation of prognostic factors for survival after radiotherapy of cerebral gliomas: A supplementary analysis to a previous study

Jaspar Witteler; Troels W. Kjaer; Soeren Tvilsted; Steven E. Schild; Dirk Rades

doi:10.21873/anticanres.14674

Re-evaluation of prognostic factors for survival after radiotherapy of cerebral gliomas: A supplementary analysis to a previous study

Jaspar Witteler, Troels W. Kjaer, Soeren Tvilsted, Steven E. Schild, Dirk Rades^*

^*Corresponding author for this work

Department of Radiotherapy

2 Citations (Scopus)

Abstract

Background/Aim: Previously, we identified predictors of survival after irradiation of grade II-IV cerebral gliomas. In this supplementary analysis, survival was calculated in a more appropriate way than the original study. Patients and Methods: Ten factors were re-evaluated for survival in patients of the original study including pre-radiotherapy seizures. In the original study, survival was calculated from the end of the last radiotherapy course (primary or re-irradiation). After re-review, this approach was considered inappropriate. Survival should have always been calculated from the first radiotherapy course, as done in this supplementary analysis. Results: On multivariate analysis, WHO-grade II (p=0.006) and upfront resection (p=0.001) were associated with better survival. Unifocal glioma was significant on univariate analysis (p=0.001), where a trend could be identified for age ≤59 years (p=0.057) and seizures (p=0.060). Conclusion: The findings of this supplementary analysis regarding the identification of prognostic factors for survival agree with the results of the original study.

Original language	English
Journal	Anticancer Research
Volume	40
Issue number	11
Pages (from-to)	6513-6515
Number of pages	3
ISSN	0250-7005
DOIs	https://doi.org/10.21873/anticanres.14674
Publication status	Published - 11.2020

Funding

As part of the NorDigHealth project, the study received funding from the European Regional Development Fund through the Interreg Deutschland-Danmark program (reference number 087-1.1-18).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.21873/anticanres.14674

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title = "Re-evaluation of prognostic factors for survival after radiotherapy of cerebral gliomas: A supplementary analysis to a previous study",

abstract = "Background/Aim: Previously, we identified predictors of survival after irradiation of grade II-IV cerebral gliomas. In this supplementary analysis, survival was calculated in a more appropriate way than the original study. Patients and Methods: Ten factors were re-evaluated for survival in patients of the original study including pre-radiotherapy seizures. In the original study, survival was calculated from the end of the last radiotherapy course (primary or re-irradiation). After re-review, this approach was considered inappropriate. Survival should have always been calculated from the first radiotherapy course, as done in this supplementary analysis. Results: On multivariate analysis, WHO-grade II (p=0.006) and upfront resection (p=0.001) were associated with better survival. Unifocal glioma was significant on univariate analysis (p=0.001), where a trend could be identified for age ≤59 years (p=0.057) and seizures (p=0.060). Conclusion: The findings of this supplementary analysis regarding the identification of prognostic factors for survival agree with the results of the original study.",

author = "Jaspar Witteler and Kjaer, \{Troels W.\} and Soeren Tvilsted and Schild, \{Steven E.\} and Dirk Rades",

note = "Funding Information: As part of the NorDigHealth project, the study received funding from the European Regional Development Fund through the Interreg Deutschland-Danmark program (reference number 087-1.1-18). Publisher Copyright: {\textcopyright} 2020 International Institute of Anticancer Research. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = nov,

doi = "10.21873/anticanres.14674",

language = "English",

volume = "40",

pages = "6513--6515",

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T1 - Re-evaluation of prognostic factors for survival after radiotherapy of cerebral gliomas: A supplementary analysis to a previous study

AU - Witteler, Jaspar

AU - Kjaer, Troels W.

AU - Tvilsted, Soeren

AU - Schild, Steven E.

AU - Rades, Dirk

N1 - Funding Information: As part of the NorDigHealth project, the study received funding from the European Regional Development Fund through the Interreg Deutschland-Danmark program (reference number 087-1.1-18). Publisher Copyright: © 2020 International Institute of Anticancer Research. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/11

Y1 - 2020/11

N2 - Background/Aim: Previously, we identified predictors of survival after irradiation of grade II-IV cerebral gliomas. In this supplementary analysis, survival was calculated in a more appropriate way than the original study. Patients and Methods: Ten factors were re-evaluated for survival in patients of the original study including pre-radiotherapy seizures. In the original study, survival was calculated from the end of the last radiotherapy course (primary or re-irradiation). After re-review, this approach was considered inappropriate. Survival should have always been calculated from the first radiotherapy course, as done in this supplementary analysis. Results: On multivariate analysis, WHO-grade II (p=0.006) and upfront resection (p=0.001) were associated with better survival. Unifocal glioma was significant on univariate analysis (p=0.001), where a trend could be identified for age ≤59 years (p=0.057) and seizures (p=0.060). Conclusion: The findings of this supplementary analysis regarding the identification of prognostic factors for survival agree with the results of the original study.

AB - Background/Aim: Previously, we identified predictors of survival after irradiation of grade II-IV cerebral gliomas. In this supplementary analysis, survival was calculated in a more appropriate way than the original study. Patients and Methods: Ten factors were re-evaluated for survival in patients of the original study including pre-radiotherapy seizures. In the original study, survival was calculated from the end of the last radiotherapy course (primary or re-irradiation). After re-review, this approach was considered inappropriate. Survival should have always been calculated from the first radiotherapy course, as done in this supplementary analysis. Results: On multivariate analysis, WHO-grade II (p=0.006) and upfront resection (p=0.001) were associated with better survival. Unifocal glioma was significant on univariate analysis (p=0.001), where a trend could be identified for age ≤59 years (p=0.057) and seizures (p=0.060). Conclusion: The findings of this supplementary analysis regarding the identification of prognostic factors for survival agree with the results of the original study.

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SN - 0250-7005

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JO - Anticancer Research

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IS - 11

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Re-evaluation of prognostic factors for survival after radiotherapy of cerebral gliomas: A supplementary analysis to a previous study

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