TY - JOUR
T1 - Re-evaluation of prognostic factors for survival after radiotherapy of cerebral gliomas: A supplementary analysis to a previous study
AU - Witteler, Jaspar
AU - Kjaer, Troels W.
AU - Tvilsted, Soeren
AU - Schild, Steven E.
AU - Rades, Dirk
N1 - Funding Information:
As part of the NorDigHealth project, the study received funding from the European Regional Development Fund through the Interreg Deutschland-Danmark program (reference number 087-1.1-18).
Publisher Copyright:
© 2020 International Institute of Anticancer Research. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11
Y1 - 2020/11
N2 - Background/Aim: Previously, we identified predictors of survival after irradiation of grade II-IV cerebral gliomas. In this supplementary analysis, survival was calculated in a more appropriate way than the original study. Patients and Methods: Ten factors were re-evaluated for survival in patients of the original study including pre-radiotherapy seizures. In the original study, survival was calculated from the end of the last radiotherapy course (primary or re-irradiation). After re-review, this approach was considered inappropriate. Survival should have always been calculated from the first radiotherapy course, as done in this supplementary analysis. Results: On multivariate analysis, WHO-grade II (p=0.006) and upfront resection (p=0.001) were associated with better survival. Unifocal glioma was significant on univariate analysis (p=0.001), where a trend could be identified for age ≤59 years (p=0.057) and seizures (p=0.060). Conclusion: The findings of this supplementary analysis regarding the identification of prognostic factors for survival agree with the results of the original study.
AB - Background/Aim: Previously, we identified predictors of survival after irradiation of grade II-IV cerebral gliomas. In this supplementary analysis, survival was calculated in a more appropriate way than the original study. Patients and Methods: Ten factors were re-evaluated for survival in patients of the original study including pre-radiotherapy seizures. In the original study, survival was calculated from the end of the last radiotherapy course (primary or re-irradiation). After re-review, this approach was considered inappropriate. Survival should have always been calculated from the first radiotherapy course, as done in this supplementary analysis. Results: On multivariate analysis, WHO-grade II (p=0.006) and upfront resection (p=0.001) were associated with better survival. Unifocal glioma was significant on univariate analysis (p=0.001), where a trend could be identified for age ≤59 years (p=0.057) and seizures (p=0.060). Conclusion: The findings of this supplementary analysis regarding the identification of prognostic factors for survival agree with the results of the original study.
UR - http://www.scopus.com/inward/record.url?scp=85094807592&partnerID=8YFLogxK
U2 - 10.21873/anticanres.14674
DO - 10.21873/anticanres.14674
M3 - Journal articles
C2 - 33109591
AN - SCOPUS:85094807592
SN - 0250-7005
VL - 40
SP - 6513
EP - 6515
JO - Anticancer Research
JF - Anticancer Research
IS - 11
ER -
