Rare human IFNG variants

Thorsten Thye; Christa Ehmen; Christopher D. Intemann; Margaret Amanua Chinbuah; Andreas Ziegler; Rolf D. Horstmann; Christian G. Meyer

doi:10.1089/jir.2009.0042

Rare human IFNG variants

Thorsten Thye, Christa Ehmen, Christopher D. Intemann, Margaret Amanua Chinbuah, Andreas Ziegler, Rolf D. Horstmann, Christian G. Meyer

Institute of Medical Biometry and Statistics

Bernhard Nocht Institute for Tropical Medicine

Abstract

After the identification of the human interferon-gamma (IFNG) variant G54D (c.287G>A, ss105106770) in DNA samples from Ghana, West Africa, systematic mutation screening of IFNG by the LightCycler®-based procedure of high-resolution melting (HRM) revealed additional rare mutations. All variants occurred heterozygously only and were confirmed either by their detection in other individuals and/or by repeated DNA sequencing of independent PCR products.

Original language	English
Journal	Journal of Interferon and Cytokine Research
Volume	30
Issue number	4
Pages (from-to)	219-222
Number of pages	4
ISSN	1079-9907
DOIs	https://doi.org/10.1089/jir.2009.0042
Publication status	Published - 01.04.2010

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SDG 3 Good Health and Well-being

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10.1089/jir.2009.0042

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title = "Rare human IFNG variants",

abstract = "After the identification of the human interferon-gamma (IFNG) variant G54D (c.287G>A, ss105106770) in DNA samples from Ghana, West Africa, systematic mutation screening of IFNG by the LightCycler{\textregistered}-based procedure of high-resolution melting (HRM) revealed additional rare mutations. All variants occurred heterozygously only and were confirmed either by their detection in other individuals and/or by repeated DNA sequencing of independent PCR products.",

author = "Thorsten Thye and Christa Ehmen and Intemann, \{Christopher D.\} and Chinbuah, \{Margaret Amanua\} and Andreas Ziegler and Horstmann, \{Rolf D.\} and Meyer, \{Christian G.\}",

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AU - Thye, Thorsten

AU - Ehmen, Christa

AU - Intemann, Christopher D.

AU - Chinbuah, Margaret Amanua

AU - Ziegler, Andreas

AU - Horstmann, Rolf D.

AU - Meyer, Christian G.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - After the identification of the human interferon-gamma (IFNG) variant G54D (c.287G>A, ss105106770) in DNA samples from Ghana, West Africa, systematic mutation screening of IFNG by the LightCycler®-based procedure of high-resolution melting (HRM) revealed additional rare mutations. All variants occurred heterozygously only and were confirmed either by their detection in other individuals and/or by repeated DNA sequencing of independent PCR products.

AB - After the identification of the human interferon-gamma (IFNG) variant G54D (c.287G>A, ss105106770) in DNA samples from Ghana, West Africa, systematic mutation screening of IFNG by the LightCycler®-based procedure of high-resolution melting (HRM) revealed additional rare mutations. All variants occurred heterozygously only and were confirmed either by their detection in other individuals and/or by repeated DNA sequencing of independent PCR products.

UR - https://www.scopus.com/pages/publications/77952522092

U2 - 10.1089/jir.2009.0042

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M3 - Journal articles

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AN - SCOPUS:77952522092

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EP - 222

JO - Journal of Interferon and Cytokine Research

JF - Journal of Interferon and Cytokine Research

IS - 4

ER -

Rare human IFNG variants

Abstract

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