Rare human IFNG variants

Thorsten Thye, Christa Ehmen, Christopher D. Intemann, Margaret Amanua Chinbuah, Andreas Ziegler, Rolf D. Horstmann, Christian G. Meyer


After the identification of the human interferon-gamma (IFNG) variant G54D (c.287G>A, ss105106770) in DNA samples from Ghana, West Africa, systematic mutation screening of IFNG by the LightCycler®-based procedure of high-resolution melting (HRM) revealed additional rare mutations. All variants occurred heterozygously only and were confirmed either by their detection in other individuals and/or by repeated DNA sequencing of independent PCR products.

Original languageEnglish
JournalJournal of Interferon and Cytokine Research
Issue number4
Pages (from-to)219-222
Number of pages4
Publication statusPublished - 01.04.2010


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