Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA

Sabrina Klein; Sébastien Boutin; Kaan Kocer; Mascha O. Fiedler; Dominic Störzinger; Markus A. Weigand; Benjamin Tan; Daniel Richter; Christian Rupp; Markus Mieth; Arianeb Mehrabi; Thilo Hackert; Stefan Zimmermann; Klaus Heeg; Dennis Nurjadi

doi:10.1093/cid/ciab511

Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA

Sabrina Klein, Sébastien Boutin, Kaan Kocer, Mascha O. Fiedler, Dominic Störzinger, Markus A. Weigand, Benjamin Tan, Daniel Richter, Christian Rupp, Markus Mieth, Arianeb Mehrabi, Thilo Hackert, Stefan Zimmermann, Klaus Heeg, Dennis Nurjadi^*

^*Corresponding author for this work

Ruprecht-Karls Universität Heidelberg

101 Citations (Scopus)

Abstract

We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.

Original language	English
Journal	Clinical Infectious Diseases
Volume	74
Issue number	5
Pages (from-to)	905-908
Number of pages	4
ISSN	1058-4838
DOIs	https://doi.org/10.1093/cid/ciab511
Publication status	Published - 01.03.2022

Access to Document

10.1093/cid/ciab511

Cite this

Klein, S., Boutin, S., Kocer, K., Fiedler, M. O., Störzinger, D., Weigand, M. A., Tan, B., Richter, D., Rupp, C., Mieth, M., Mehrabi, A., Hackert, T., Zimmermann, S., Heeg, K., & Nurjadi, D. (2022). Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA. Clinical Infectious Diseases, 74(5), 905-908. https://doi.org/10.1093/cid/ciab511

@article{fda4d0c07876480aa09ab0873817a9ac,

title = "Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA",

abstract = "We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.",

author = "Sabrina Klein and S{\'e}bastien Boutin and Kaan Kocer and Fiedler, \{Mascha O.\} and Dominic St{\"o}rzinger and Weigand, \{Markus A.\} and Benjamin Tan and Daniel Richter and Christian Rupp and Markus Mieth and Arianeb Mehrabi and Thilo Hackert and Stefan Zimmermann and Klaus Heeg and Dennis Nurjadi",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s).",

year = "2022",

month = mar,

day = "1",

doi = "10.1093/cid/ciab511",

language = "English",

volume = "74",

pages = "905--908",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "5",

}

Klein, S, Boutin, S , Kocer, K, Fiedler, MO, Störzinger, D, Weigand, MA, Tan, B, Richter, D, Rupp, C, Mieth, M, Mehrabi, A, Hackert, T, Zimmermann, S, Heeg, K & Nurjadi, D 2022, 'Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA', Clinical Infectious Diseases, vol. 74, no. 5, pp. 905-908. https://doi.org/10.1093/cid/ciab511

Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA. / Klein, Sabrina; Boutin, Sébastien ; Kocer, Kaan et al.
In: Clinical Infectious Diseases, Vol. 74, No. 5, 01.03.2022, p. 905-908.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA

AU - Klein, Sabrina

AU - Boutin, Sébastien

AU - Kocer, Kaan

AU - Fiedler, Mascha O.

AU - Störzinger, Dominic

AU - Weigand, Markus A.

AU - Tan, Benjamin

AU - Richter, Daniel

AU - Rupp, Christian

AU - Mieth, Markus

AU - Mehrabi, Arianeb

AU - Hackert, Thilo

AU - Zimmermann, Stefan

AU - Heeg, Klaus

AU - Nurjadi, Dennis

PY - 2022/3/1

Y1 - 2022/3/1

N2 - We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.

AB - We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.

UR - https://www.scopus.com/pages/publications/85122476333

U2 - 10.1093/cid/ciab511

DO - 10.1093/cid/ciab511

M3 - Journal articles

C2 - 34079986

AN - SCOPUS:85122476333

SN - 1058-4838

VL - 74

SP - 905

EP - 908

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 5

ER -

Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA

Abstract

Access to Document

Other files and links

Fingerprint

Cite this