Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA.

Sabrina Klein; Sébastien Boutin; Kaan Kocer; Mascha O. Fiedler; Dominic Störzinger; Markus A. Weigand; Benjamin Tan; Daniel Richter; Christian Rupp; Markus Mieth; Arianeb Mehrabi; Thilo Hackert; Stefan Zimmermann; Klaus Heeg; Dennis Nurjadi

Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA.

Sabrina Klein, Sébastien Boutin, Kaan Kocer, Mascha O. Fiedler, Dominic Störzinger, Markus A. Weigand, Benjamin Tan, Daniel Richter, Christian Rupp, Markus Mieth, Arianeb Mehrabi, Thilo Hackert, Stefan Zimmermann, Klaus Heeg, Dennis Nurjadi

Translational Lung Research Center Heidelberg (TLRC)

Abstract

We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.

Original language	English
Journal	Clin Infect Dis
Issue number	5
ISSN	1058-4838
Publication status	Published - 01.03.2022

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Klein, S., Boutin, S., Kocer, K., Fiedler, M. O., Störzinger, D., Weigand, M. A., Tan, B., Richter, D., Rupp, C., Mieth, M., Mehrabi, A., Hackert, T., Zimmermann, S., Heeg, K., & Nurjadi, D. (2022). Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA. Clin Infect Dis, (5).

@article{b4ad2812f84c424eaaee26f19c884166,

title = "Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA.",

abstract = "We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.",

author = "Sabrina Klein and S{\'e}bastien Boutin and Kaan Kocer and Fiedler, {Mascha O.} and Dominic St{\"o}rzinger and Weigand, {Markus A.} and Benjamin Tan and Daniel Richter and Christian Rupp and Markus Mieth and Arianeb Mehrabi and Thilo Hackert and Stefan Zimmermann and Klaus Heeg and Dennis Nurjadi",

note = "Place: United States",

year = "2022",

month = mar,

day = "1",

language = "English",

journal = "Clin Infect Dis",

issn = "1058-4838",

number = "5",

}

Klein, S, Boutin, S, Kocer, K, Fiedler, MO, Störzinger, D, Weigand, MA, Tan, B, Richter, D, Rupp, C, Mieth, M, Mehrabi, A, Hackert, T, Zimmermann, S, Heeg, K & Nurjadi, D 2022, 'Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA.', Clin Infect Dis, no. 5.

Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA. / Klein, Sabrina; Boutin, Sébastien; Kocer, Kaan et al.
In: Clin Infect Dis, No. 5, 01.03.2022.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA.

AU - Klein, Sabrina

AU - Boutin, Sébastien

AU - Kocer, Kaan

AU - Fiedler, Mascha O.

AU - Störzinger, Dominic

AU - Weigand, Markus A.

AU - Tan, Benjamin

AU - Richter, Daniel

AU - Rupp, Christian

AU - Mieth, Markus

AU - Mehrabi, Arianeb

AU - Hackert, Thilo

AU - Zimmermann, Stefan

AU - Heeg, Klaus

AU - Nurjadi, Dennis

N1 - Place: United States

PY - 2022/3/1

Y1 - 2022/3/1

N2 - We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.

AB - We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.

M3 - Journal articles

SN - 1058-4838

JO - Clin Infect Dis

JF - Clin Infect Dis

IS - 5

ER -

Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA.

Abstract

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