Radiotherapy with and without cisplatin in bladder cancer

R. Sauer, J. Dunst, A. Altendorf-Hofmann, H. Fischer, C. Bornhof, K. M. Schrott

72 Citations (Scopus)


From October 1985 to December 1988,67 patients with invasive bladder carcinoma T1-4 N0-2M0 were treated with irradiation (50.4 Gy in 28 fractions in 6 weeks) and simultaneous cisplatin (25 mg/m2 per day on 5 consecutive days in the first and fifth irradiation week). After transurethral resection and irradiation plus cisplatin, complete remissions were achieved in 8 11 T1-, 14 16 T2-, 27 36 T3- and 1 4 T4-tumors. The complete remission rate 6 weeks after treatment according to the extent of preceeding transurethral surgery (TUR) was: R0: 67% ( 8 12); R1: 83% ( 20 24); R2: 70% ( 21 30); Rx: 1 1. In patients with incomplete TUR (R1-2), the complete remission rate was 76% ( 41 54). This was superior to the results of a historical control (76% vs. 45%, p < 0.01). The estimated 3-year survival according to T-stage was: T1: 73%, T2-3: 68%, T4: 25%. The overall 3-year survival was unchanged as compared to our historical control (66% each). Severe complications have not been observed. We conclude that cisplatin will likely increase the local control rate after incomplete transurethral surgery. An improvement of survival seems unlikely.

Original languageEnglish
JournalInternational journal of radiation oncology, biology, physics
Issue number3
Pages (from-to)687-691
Number of pages5
Publication statusPublished - 09.1990


Dive into the research topics of 'Radiotherapy with and without cisplatin in bladder cancer'. Together they form a unique fingerprint.

Cite this