Radiotherapy in multilocalized lymphedema-associated angiosarcoma

Beate Danz, Andrea Hellmann, Volker Stadie, Jürgen Dunst, Christine Richter, Wolfgang Ch Marsch, Peter Helmbold*

*Corresponding author for this work
5 Citations (Scopus)


We report an 80-year-old woman, suffering from a recurrence of a multilocalized lymphedema-associated angiosarcoma of the right arm. The tumor consisted of solid tumor cell formations and "classical" spongiform tumor complexes. In the tumor periphery, pathological endothelial cell proliferates on pre-existing dilated lymphatic capillaries were detectable, which, together with immunohistology (CD 31+/Desmoplakin-1-2.17+/CD 34-), supported the diagnosis of lymphangiosarcoma. Complete remission was achieved under radioimmuno-therapy (54 Gy/Interferon β). A further recurrence 3 months later outside the primary therapy fields was successfully treated with radiotherapy alone. During a follow-up observation period of 3 years, there was neither local recurrence nor metastasis. This case demonstrates for the first time the long-lasting efficacy of photon radiation in a case of histologically-defined lymphangiosarcoma. Further studies should elucidate the suitability of radio monotherapy as first-line therapy in lymphedema-associated angiosarcoma with lymphatic endothelium-like immunohistology.

Original languageEnglish
JournalEuropean Journal of Dermatology
Issue number6
Pages (from-to)474-477
Number of pages4
Publication statusPublished - 11.2005


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