Radiological findings in individuals at high risk of psychosis

S. J. Borgwardt; E. W. Radue; K. Götz; J. Aston; M. Drewe; U. Gschwandtner; S. Haller; M. Pflüger; R. D. Stieglitz; P. K. McGuire; Anita Riecher-Rössler

doi:10.1136/jnnp.2005.069690

Radiological findings in individuals at high risk of psychosis

S. J. Borgwardt, E. W. Radue, K. Götz, J. Aston, M. Drewe, U. Gschwandtner, S. Haller, M. Pflüger, R. D. Stieglitz, P. K. McGuire, Anita Riecher-Rössler^*

^*Corresponding author for this work

52 Citations (Scopus)

Abstract

Objective: To assess the prevalence of radiological magnetic resonance imaging (MRI) findings in individuals at high risk of schizophrenia. Methods: MRI scans from individuals at high risk of schizophrenia (HR; n = 37) were assessed by a radiologist blind to group status and compared with scans from patients with first episode psychosis (FE; n = 30), depressive controls (DC; n = 17), and healthy controls (HC; n = 26). Results: There was a significantly higher proportion of radiological findings in individuals at high risk of schizophrenia (35%) and patients with first-episode psychosis (40%) than in patients with depression (18%) or healthy controls (12%). These differences were specific to findings regarded as potentially clinically significant as opposed to normal variants; however, there was no indication for medical treatment. Conclusions: The results suggest that a large proportion of those at high risk of psychosis have radiological findings on MRI scanning, and that the prevalence of radiological findings in this group is similar to that in patients with first episode psychosis.

Original language	English
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	77
Issue number	2
Pages (from-to)	229-233
Number of pages	5
ISSN	0022-3050
DOIs	https://doi.org/10.1136/jnnp.2005.069690
Publication status	Published - 02.2006

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SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

2.22-07 Medical Informatics and Medical Bioinformatics

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10.1136/jnnp.2005.069690

Cite this

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title = "Radiological findings in individuals at high risk of psychosis",

abstract = "Objective: To assess the prevalence of radiological magnetic resonance imaging (MRI) findings in individuals at high risk of schizophrenia. Methods: MRI scans from individuals at high risk of schizophrenia (HR; n = 37) were assessed by a radiologist blind to group status and compared with scans from patients with first episode psychosis (FE; n = 30), depressive controls (DC; n = 17), and healthy controls (HC; n = 26). Results: There was a significantly higher proportion of radiological findings in individuals at high risk of schizophrenia (35\%) and patients with first-episode psychosis (40\%) than in patients with depression (18\%) or healthy controls (12\%). These differences were specific to findings regarded as potentially clinically significant as opposed to normal variants; however, there was no indication for medical treatment. Conclusions: The results suggest that a large proportion of those at high risk of psychosis have radiological findings on MRI scanning, and that the prevalence of radiological findings in this group is similar to that in patients with first episode psychosis.",

author = "Borgwardt, \{S. J.\} and Radue, \{E. W.\} and K. G{\"o}tz and J. Aston and M. Drewe and U. Gschwandtner and S. Haller and M. Pfl{\"u}ger and Stieglitz, \{R. D.\} and McGuire, \{P. K.\} and Anita Riecher-R{\"o}ssler",

year = "2006",

month = feb,

doi = "10.1136/jnnp.2005.069690",

language = "English",

volume = "77",

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T1 - Radiological findings in individuals at high risk of psychosis

AU - Borgwardt, S. J.

AU - Radue, E. W.

AU - Götz, K.

AU - Aston, J.

AU - Drewe, M.

AU - Gschwandtner, U.

AU - Haller, S.

AU - Pflüger, M.

AU - Stieglitz, R. D.

AU - McGuire, P. K.

AU - Riecher-Rössler, Anita

PY - 2006/2

Y1 - 2006/2

N2 - Objective: To assess the prevalence of radiological magnetic resonance imaging (MRI) findings in individuals at high risk of schizophrenia. Methods: MRI scans from individuals at high risk of schizophrenia (HR; n = 37) were assessed by a radiologist blind to group status and compared with scans from patients with first episode psychosis (FE; n = 30), depressive controls (DC; n = 17), and healthy controls (HC; n = 26). Results: There was a significantly higher proportion of radiological findings in individuals at high risk of schizophrenia (35%) and patients with first-episode psychosis (40%) than in patients with depression (18%) or healthy controls (12%). These differences were specific to findings regarded as potentially clinically significant as opposed to normal variants; however, there was no indication for medical treatment. Conclusions: The results suggest that a large proportion of those at high risk of psychosis have radiological findings on MRI scanning, and that the prevalence of radiological findings in this group is similar to that in patients with first episode psychosis.

AB - Objective: To assess the prevalence of radiological magnetic resonance imaging (MRI) findings in individuals at high risk of schizophrenia. Methods: MRI scans from individuals at high risk of schizophrenia (HR; n = 37) were assessed by a radiologist blind to group status and compared with scans from patients with first episode psychosis (FE; n = 30), depressive controls (DC; n = 17), and healthy controls (HC; n = 26). Results: There was a significantly higher proportion of radiological findings in individuals at high risk of schizophrenia (35%) and patients with first-episode psychosis (40%) than in patients with depression (18%) or healthy controls (12%). These differences were specific to findings regarded as potentially clinically significant as opposed to normal variants; however, there was no indication for medical treatment. Conclusions: The results suggest that a large proportion of those at high risk of psychosis have radiological findings on MRI scanning, and that the prevalence of radiological findings in this group is similar to that in patients with first episode psychosis.

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DO - 10.1136/jnnp.2005.069690

M3 - Journal articles

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VL - 77

SP - 229

EP - 233

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

IS - 2

ER -

Radiological findings in individuals at high risk of psychosis

Abstract

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