Radiation therapy alone provides excellent outcomes for spinal cord compression from vertebral lymphoma

Dirk Rades; Antonio J. Conde-Moreno; Jon Cacicedo; Barbara Ŝegedin; Volker Rudat; Steven E. Schild

Radiation therapy alone provides excellent outcomes for spinal cord compression from vertebral lymphoma

Dirk Rades^*, Antonio J. Conde-Moreno, Jon Cacicedo, Barbara Ŝegedin, Volker Rudat, Steven E. Schild

^*Corresponding author for this work

Clinic of Radiotherapy

1 Citation (Scopus)

Abstract

Aim: Malignant spinal cord compression (SCC) is treated with radiotherapy (RT). Additional neurosurgery has become more widely used since a trial showed a benefit for selected patients. Although lymphomas were excluded from that trial, neurosurgery is also increasingly being performed in these patients. This study investigated whether neurosurgery is actually required for this group. Patients and Methods: Twenty-nine patients receiving RT alone for SCC from vertebral lymphoma were analyzed for motor function, walking ability, in-field recurrence and survival. Results: Overall response was 100% (72% improvement, 28% stable). At 1, 6 and 12 months after RT, 83%, 100% and 100% of patients were able to walk; 64%, 100%, and 100% of nonambulatory patients regained their walking ability. Freedom from in-field recurrence was 100% at 6 and 12 months. Survival rates at 6 and 12 months were 79% and 75%. Conclusion: RT alone resulted in excellent outcomes for SCC from lymphoma. These patients may not require surgery.

Original language	English
Journal	Anticancer Research
Volume	36
Issue number	6
Pages (from-to)	3081-3083
Number of pages	3
ISSN	0250-7005
Publication status	Published - 06.2016

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Cite this

@article{087d7d432f114ce68d9942d2449ca10a,

title = "Radiation therapy alone provides excellent outcomes for spinal cord compression from vertebral lymphoma",

abstract = "Aim: Malignant spinal cord compression (SCC) is treated with radiotherapy (RT). Additional neurosurgery has become more widely used since a trial showed a benefit for selected patients. Although lymphomas were excluded from that trial, neurosurgery is also increasingly being performed in these patients. This study investigated whether neurosurgery is actually required for this group. Patients and Methods: Twenty-nine patients receiving RT alone for SCC from vertebral lymphoma were analyzed for motor function, walking ability, in-field recurrence and survival. Results: Overall response was 100% (72% improvement, 28% stable). At 1, 6 and 12 months after RT, 83%, 100% and 100% of patients were able to walk; 64%, 100%, and 100% of nonambulatory patients regained their walking ability. Freedom from in-field recurrence was 100% at 6 and 12 months. Survival rates at 6 and 12 months were 79% and 75%. Conclusion: RT alone resulted in excellent outcomes for SCC from lymphoma. These patients may not require surgery.",

author = "Dirk Rades and Conde-Moreno, {Antonio J.} and Jon Cacicedo and Barbara Ŝegedin and Volker Rudat and Schild, {Steven E.}",

year = "2016",

month = jun,

language = "English",

volume = "36",

pages = "3081--3083",

journal = "Anticancer Research",

issn = "0250-7005",

number = "6",

}

TY - JOUR

T1 - Radiation therapy alone provides excellent outcomes for spinal cord compression from vertebral lymphoma

AU - Rades, Dirk

AU - Conde-Moreno, Antonio J.

AU - Cacicedo, Jon

AU - Ŝegedin, Barbara

AU - Rudat, Volker

AU - Schild, Steven E.

PY - 2016/6

Y1 - 2016/6

N2 - Aim: Malignant spinal cord compression (SCC) is treated with radiotherapy (RT). Additional neurosurgery has become more widely used since a trial showed a benefit for selected patients. Although lymphomas were excluded from that trial, neurosurgery is also increasingly being performed in these patients. This study investigated whether neurosurgery is actually required for this group. Patients and Methods: Twenty-nine patients receiving RT alone for SCC from vertebral lymphoma were analyzed for motor function, walking ability, in-field recurrence and survival. Results: Overall response was 100% (72% improvement, 28% stable). At 1, 6 and 12 months after RT, 83%, 100% and 100% of patients were able to walk; 64%, 100%, and 100% of nonambulatory patients regained their walking ability. Freedom from in-field recurrence was 100% at 6 and 12 months. Survival rates at 6 and 12 months were 79% and 75%. Conclusion: RT alone resulted in excellent outcomes for SCC from lymphoma. These patients may not require surgery.

AB - Aim: Malignant spinal cord compression (SCC) is treated with radiotherapy (RT). Additional neurosurgery has become more widely used since a trial showed a benefit for selected patients. Although lymphomas were excluded from that trial, neurosurgery is also increasingly being performed in these patients. This study investigated whether neurosurgery is actually required for this group. Patients and Methods: Twenty-nine patients receiving RT alone for SCC from vertebral lymphoma were analyzed for motor function, walking ability, in-field recurrence and survival. Results: Overall response was 100% (72% improvement, 28% stable). At 1, 6 and 12 months after RT, 83%, 100% and 100% of patients were able to walk; 64%, 100%, and 100% of nonambulatory patients regained their walking ability. Freedom from in-field recurrence was 100% at 6 and 12 months. Survival rates at 6 and 12 months were 79% and 75%. Conclusion: RT alone resulted in excellent outcomes for SCC from lymphoma. These patients may not require surgery.

UR - http://www.scopus.com/inward/record.url?scp=84991704615&partnerID=8YFLogxK

M3 - Journal articles

C2 - 27272831

AN - SCOPUS:84991704615

SN - 0250-7005

VL - 36

SP - 3081

EP - 3083

JO - Anticancer Research

JF - Anticancer Research

IS - 6

ER -

Radiation therapy alone provides excellent outcomes for spinal cord compression from vertebral lymphoma

Abstract

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